Objective: This study produced a fungal chitosan membrane extracted from Rhizopus stolonifer, as well as its modification using dielectric barrier discharge plasma (DBD), aiming to improve the physicochemical characteristics of the membrane, optimizing its use in the medical research field. Method: The obtained chitosan was physically and chemically characterized (Molecular Weight, Fourier Transform Infrared, X-ray Diffraction), later were produced fungal chitosan membranes and DBD plasma was applied. The membranes were characterized before and after plasma application using the tests contact angle, swelling and atomic force microscopy (medium roughness) analyzes. Results: A fungal chitosan with a yield of 16.73 mg/g, and an apparent molecular weight of 4 kDa was obtained, being considered of low molecular weight and high degree of deacetylation (84%). It was possible to obtain the membrane and after application of DBD plasma, the contact angle dropped from 77.5° to 30.9°, making it more hydrophilic. Conclusion: Thus, the efficiency of the technique for increasing the hydrophilicity of the fungal chitosan membrane without the additive of chemical reagents during the process was confirmed and the membrane formed is a promising alternative can be used in different ways in the medical area.

Foodborne Diseases (FBD) affect millions of people worldwide. They are caused mainly by bacteria of the genus Staphylococcus, mainly Staphylococcus aureus. Among these, some produce enterotoxins that are resistant to high temperatures and can contaminate various types of foods such as milk and dairy products, in addition to meat products and others. For these reasons, it is necessary to study S aureus and Staphylococcal Enterotoxins (SE), which are the main causes of FBD, and the development of actions and new products that maintain the health of food, especially milk, daity dirivates and meat products, in order to reduce contamination. In addition to the study of more efficient techniques for detecting these contaminating agents. Among these techniques, molecular techniques stand out, which currently have been shown to be increasingly sensitive and specific. In general, the association of good hygiene practices and molecular detection techniques are fundamental for maintaining food health, avoiding losses in the industry and serious health problems.

The World Health Organization (WHO) defines the adverse reaction to the medication as a harmful or unwanted reaction that appears after the administration of a medicines used to prevent or treat a disease or symptoms. The irrational use of medications is a serious problem and is related when the patient purchases medicines with no indication or professional guidance on their use. This leads to exposure to problems related to medications, as well as adverse reactions, directing the population to Primary Care units. In this context, there is a need for the insertion of the pharmacist providing clinical services in these units. The work aimed to carry out a systematic review of the literature of studies on Pharmaceutical Care in Basic Health Units and the impacts on the irrational use of medicines, as well as the role of the pharmacist in this process. Initially, 53 articles were selected from the SciELO, LILACS and BVS databases, where only 2 articles met the inclusion criteria of the review. It was evident that the monitoring of a professional providing Pharmaceutical Care and guiding patients to the best use of their medicines received in Primary Care is beneficial to the health of the population. Just as this professional would increase the number of assisted inhabitants, in addition to reducing the practice of self-medication. In addition, the authors of both articles also show that the importance of the pharmacist in Primary Care, acting in addition to Pharmaceutical Assistance, also in Pharmaceutical Care, presents better management of resources used in the municipality's pharmacy.

Gestational Diabetes Mellitus is a condition characterized by an increase in blood glucose levels, which can be initiated or diagnosed during pregnancy. This process occurs due to the production of high levels of hormones by the placenta, most of which are harmful to the action of insulin in the cells increasing the blood sugar level and can affect the growth and well-being of the fetus. Among the drugs used, Metformin Hydrochloride is an oral hypoglycemic drug used to treat Diabetes Mellitus. The present study aimed to elaborate a systematic review on the use of metformin hydrochloride in the treatment of gestational diabetes mellitus. The searches were carried out in the SciElo and Google Acadêmico databases. 763 articles were found in the initial research and after the analysis of the pre-analytical phases, only 6 were selected, since they met the inclusion criteria. After extracting the data, a relationship was made between the use of metformin with the various forms of therapy used in the studies and it was shown that metformin is a drug well applied as monotherapy, being used by 40 % of individuals in one of the studies analyzed and it is also well accepted in combination therapy with insulin in patients who have resistance to it, due to metformin being a drug with easy access and easy dosage. It is concluded that metformin is a safe, effective, low-cost and widely accepted drug for pregnant women who use it in the treatment of gestational Diabetes Mellitus.