Purpose The purpose of this study was to assess clinical characteristics and risk factors for mortality of patients with coronavirus disease 2019 (COVID-19) from Mexico, given that it currently is in active community transmission. Methods Multivariate logistic regression model and Kaplan–Meier survival curves were fitted to study odds of death of characteristics and comorbidities in patients with COVID-19 in Mexico. Results Age, sex, and the most frequent comorbidities diabetes, obesity, and hypertension were significantly associated to the risk of death by COVID-19 ( P < .0001). Smoking habit was not identified as a risk factor for death. Less-frequent comorbidities such as chronic obstructive pulmonary disease, chronic kidney disease, and patients with immunosuppressed conditions also showed a significant risk for death ( P < .0001). Hospitalized patients and those with pneumonia had serious risks for mortality ( P < .0001), and more attention to specific conditions might be considered during clinical admission. Conclusions A more vulnerable positive patient is depicted by a male patient, older than 41 years, which increases their risk with more prevalent comorbidities such as diabetes, hypertension, and obesity. Some implications on outcomes are discussed.

Chronic kidney disease (CKD) is a recognized public health problem and key determinant of poor health outcomes. In Mexico, this condition has been associated with high and significant risk of death in COVID‐19 patients; however, not enough attention has been given to the vulnerable population as the increasing numbers and fatality rates suggest. This study evaluated the effect of interaction between CKD condition and other risk factors (sex, diabetes, hypertension and obesity) on the survival rate of positive patients for COVID‐19 in Mexico. The results from this study support that CKD patients is a population at high risk for mortality for COVID‐19 and that COVID‐19 positive inpatients with CKD and diabetes are highly vulnerable to death.

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