Objectives: To investigate the degree of Men who have Sex with Men (MSM) adherence to antiretrovirals Tenofovir/Emtricitabine (TFC/FTC), drugs for the Pre-exposure Prophylaxis to the human immunodeficiency virus (PrEP). Methods: This is a cross-sectional and retrospective study carried out in a reference service in infectology in Ceará-Brazil. MSM with at least three recorded medical follow-ups were included in the study. We considered as ideal adherence those users who took at least 80% of the doses within 90 days. Bivariate analysis (X² or Fisher's exact) was carried out to investigate the association between ideal adherence to PrEP and the use of alcohol and illicit drugs. Results with a p-value <0.05 were taken into consideration. Results: A total of 167 individuals participated in the survey. MSM stopped taking 668 doses of PrEP in three months, of which 16.2% (n=27) had an adherence rate >80%. Nevertheless, alcohol and illicit drug use accounted for 41.4% (n=69). Among the most commonly used narcotics were marijuana and cocaine, 42.7% (n=35) and 18.3% (n=15), respectively. It was observed that optimal adherence (>80%) was better in individuals who did not use alcohol and illicit drugs compared to those who did (p=0.003). Conclusion: MSM adhered satisfactorily to PrEP; however, it was observed that individuals who used illicit drugs and alcohol when had their degree of adherence to TDF/FTC weakened when compared to those who did not use them. Thus, it becomes necessary to pay attention to such aspects to provide alternatives for increasing adherence in highpriority populations.
Objectives: To delineate the sociodemographic and clinical characteristics, sexual behavior, and the degree of adherence of users to Human Immunodeficiency Virus (HIV) Pre-Exposure Prophylaxis (PrEP), as well as the factors that impact their full adherence. Materials and Methods: This is an analytical, cross-sectional, retrospective study carried out in reference services in infectology. Subjects with at least three clinical monitoring of PrEP were included in the study. We considered as 'full adherence' those individuals who took 100% of the recommended doses. Bivariate and multivariate analysis was performed to investigate the association between full adherence to PrEP and selected variables. Results: Most participants were male (80.1%; n=185), homosexual (61.9%; n=143), with a mean age of 32±8.6 years. Regarding the clinical aspects, the presence of subjects with chronic kidney disease using prophylaxis drew attention. Concerning the use of PrEP, only 5.6% (n=13) had a degree of adherence lower than 80%. In this context, it was observed that user characteristics, such as meretriciousness and homosexuality, impacted full adherence to the method (p= 0.033; p=0.049, respectively). Conclusion: The results achieved pointed to high adherence to PrEP. However, it was observed that factors such as homosexuality and prostitution had a negative association with widespread adherence to prophylaxis. In this sense, clinical follow-up by a multidisciplinary team is essential, given the need to adopt strategies to strengthen the use of prophylaxis by specific groups and the existence of patients with clinical conditions that the use of PrEP can aggravate.
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