. Electron probe x-ray microanalysis of these cells showed dissipation of transmembrane gradients to sodium and potassium that was indicative of membrane disruption. The spontaneous waves of cyclic contractions were attributed to the oscillatory release and reuptake of calcium by the sarcoplasmic reticulum. '-4 Repetitive contractile waves have also been found in single ventricular myocytes5-7 in association with a localized increase in intracellular calcium ([Ca2+]
This study investigates the possible role of oscillatory release of calcium from sarcoplasmic reticulum in the genesis of ventricular arrhythmias during acute myocardial ischemia and reperfusion hi isolated rat hearts. We used ryanodine and caffeine, which are known to modulate the oscillatory release of calcium from sarcoplasmic reticulum.
The A-to-G mutation at position 8344 in the transfer RNAlysine mitochondrial DNA gene is associated mostly with the myoclonic epilepsy and ragged red fibers syndrome. We describe a five-generation family with this mutation and 19 affected members with a variant neurologic syndrome of ataxia, myopathy, hearing loss, and neuropathy. Along with axial lipomas and diabetes mellitus, hypertension is a frequent somatic feature, suggesting that mitochondrial mutations may contribute to hypertension in these patients.
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