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Acute appendicitis is possibly the most frequent reason for admission to any surgical unit worldwide. Approximately 5% to 8% of the population in Western countries would have appendicitis sometime during their life, with a peak incidence between 10 and 30 years of age 1. The clinical presentation of periumbilical pain radiating to the right lower quadrant followed by anorexia and tenderness are unfortunately not a constant feature of acute appendicitis and usually present only in 37% to 53% of patients. The symptoms could be the initial

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The reaction of twenty four hour old primitive streak chick embryoblasts exposed to epidermal growth factor was compared with non-exposed controls. After 24-36 hours incubation, proliferation up to 5-6 cell layers in thickness of the epiblast-hypoblast layers was evident in the EGF exposed embryo blasts. This compared with the normally expected one cell layer in thickness at this stage of development.