In this work, a multi-scale optimization strategy for lightweight structures, based on a global-local modelling approach is presented. The approach is applied to a realistic wing structure of a civil aircraft. The preliminary design of the wing can be formulated as a constrained optimization problem, involving several requirements at the dierent scales of the structure. The proposed strategy is characterized by two main features. Firstly, the problem is formulated in the most general sense, by including all design variables involved at each problem scale. Secondly, two scales are considered: (i) the structure macroscopic scale, where low-delity numerical models are used; (ii) the structure mesoscopic scale (or component-level), where enhanced models are involved. In particular, the structural responses are evaluated at both global and local scales, avoiding the use of approximated analytical methods. To this end, fully parametric global and local nite element models are interfaced with an in-house genetic algorithm. Rened models are created only for the most critical regions of the structure, and linked to the global one by means of a dedicated sub-modelling approach.
Osteogenesis Imperfecta (OI) is a heterogeneous group of inherited skeletal dysplasias characterized by bone fragility. The study of bone metabolism, in these disease, is problematic in terms of clinical and genetic variability. The aims of our study were to evaluate the importance of Vitamin D levels in OI bone metabolism, reviewing studies performed on this topic and providing advice reflecting our experience using vitamin D supplementation. A comprehensive review on all English-language articles was conducted in order to analyze the influence of vitamin D in OI bone metabolism in pediatric patients. Reviewing the studies, contradictory data were found on the relationship between 25OH vitamin D levels and bone parameters in OI, and in several studies the baseline levels of 25OH D were below the threshold value of 75 nmol/L. In conclusion, according to the literature and to our experience, we highlight the importance of adequate vitamin D supplementation in children with OI.
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