Purpose: Nystagmus can severely impact the visual function, lifestyle and quality of life of patients. Patient with Nystagmus may assume an abnormal compensatory head position and it can result in posture disorders. Botulinum toxin is an important treatment for much pathology of the eye, in particular for blepharospasm, strabismus and nystagmus. The mechanism of action is to prevent lease of acetylcholine in the neuromuscular junction getting the neuromuscular blockade and transient flaccid paralysis. The objective of this work is to evaluate the efficacy of botulinum toxin injection in patients with Nystagmus. Methods: n. 6 patients, (3 females and 3 males) aged 17 -35 years, exhibiting exotropia (XT) associated with Nystagmus received an injection of Botulinum Toxin A Dysport (Ipsen) in the Lateral Muscles of each eye with a 27-gauge retrobulbar needle. Patients underwent an orthoptic and ophthalmic eye exam before and after surgery. Results: A significant reduction of the nystagmus in primary position was reported in all patients; the abnormal position of the head was noticeably reduced. Side-effects were limited and well tolerated by the patients. Conclusion: Botulinum toxin injection is a valuable treatment of Nystagmus associated with exotropia.
Purpose: The aim of our study was to assess the variations in fusion and stereopsis before and after refractive surgery. Methods: We conducted a retrospective study. 140 patients (78 M, 62 F) were selected, aged 20 -59 years (mean age 36 ± 10 DS). All patients received a comprehensive ophtalmological and orthoptic examination. Surgery was performed using a MEL-80 excimer laser (Carl Zeiss Meditec, Jena, Germany). Results. Fusional convergence amplitudes after refractive eye surgery range from at near 18 -20 PD in 42 (30%) patients; 25 -30 PD in 56 (40%) patients; 35 -40 PD in 42 (30%) patients, at far 20 -25 PD in 84 (60%) patients; 30 -40 PD in 56 (40%) patients, fusional divergence at near after refractive eye surgery range from at near 6 -8 PD in 108 (75.7%) patients; 10 -12 PD in 52 (37.1%), at far 6 -8 PD in 126 (90%) patients; 10 -12 PD in 14 (10%) patients. None of the patients developed any ocular deviations. NCP, on average, decreases from 9.4 ± 1.5 cm to 9.1 ± 0.9 cm after. None of these patients with a normal NCP before surgery developed an abnormal NCP after refractive surgery. Eighteen patients (12.8%) had a stereopsis higher than 60 s of arch before surgical intervention. Of these, in 2 cases (2.8%) stereopsis increased from 200 to 40 s of arch after surgery. In the rest of patients stereopsis remained unchanged. Conclusion: The increase in fusion at near appears to be considerably interesting, whereas there is no worsening of stereopsis. A careful pre-surgery orthoptic evaluation is extremely revelant for a safe refractive surgery, this reducing the risk of complications associated with fusion and stereopsis.
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