Peripheral nerve injury continues to pose a clinical hurdle despite its frequency and advances in treatment. Unlike the central nervous system, neurons of the peripheral nervous system have a greater ability to regenerate. However, due to a number of confounding factors, this is often both incomplete and inadequate. The lack of supportive Schwann cells or their inability to maintain a regenerative phenotype is a major factor. Advances in nervous system tissue engineering technology have led to efforts to build Schwann cell scaffolds to overcome this and enhance the regenerative capacity of neurons following injury. Stem cells that can differentiate along a neural lineage represent an essential resource and starting material for this process. In this review, we discuss the different stem cell types that are showing promise for nervous system tissue engineering in the context of peripheral nerve injury. We also discuss some of the biological, practical, ethical, and commercial considerations in using these different stem cells for future clinical application.

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Water security is a hot topic all over the world, due to global warming, climate change, natural calamities such as droughts and floods, overuse of water, and other factors. Water issues have been scientifically investigated from several perspectives, namely institutional, economic, social, environmental, managerial, and technological. However, the technological aspects of irrigation and water supply for smallholder farmers in the Mediterranean region have not been adequately addressed. This paper explores irrigation and water supply technologies for smallholder farmers in the selected Mediterranean countries (Egypt, Malta, Morocco, and Portugal). The methods of analysis are literature review, fieldwork, and observation. The literature survey reveals that Mediterranean countries share many common features in terms of climate, water and land resources, and development issues. Nevertheless, the selected countries in the Mediterranean region (Egypt, Malta, Morocco, and Portugal) differ in terms of type of crops, water management regulations, labor force availability, financial sustainability, and economic approaches. These remarks signal the need for applying a specific approach in selecting a technology for irrigation and water supply according to the regional context. Additionally, the financial and economic perspectives of the three key technologies (i.e., SLECI, desalination technology, and engineering constructed wetlands) require further analysis.