Objective-We evaluated the bladder cancer risk associated with coffee consumption in a casecontrol study in Spain and examined the gene-environment interactions for genetic variants of caffeine metabolizing enzymes.Methods-The analyses included 1136 incident cases with urothelial carcinoma of the urinary bladder and 1138 controls. Odds ratios (OR) and 95% confidence intervals (CI) were adjusted for area, age, gender, amount of cigarette smoking and years since quitting among former smokers.Results-The OR (95%CI) for ever consumed coffee was 1.25 (0.95-1.64). For consumers of 1, 2, 3 and 4 or more cups/day relative to never drinkers, OR were, respectively: 1.24 (0.92-1.66), 1.11 (95%CI 0.82-1.51), 1.57 (1.13-2.19) and 1.27 (0.88-1.81). Coffee consumption was higher in smokers compared to never smokers. The OR for drinking at least 4 cups/day was: 1.13 (0.61-2.09) in current smokers, 1.57 (0.86-2.90) in former smokers, and 1. 23 (0.55-2.76)
Most protein half-lives are equal to cell-cycle length Net synthesis rates of 18 test proteins are 2-fold higher than their decay rates Most tested proteins segregate stochastically between mothers and daughters ''Old'' Rxt3p, Tup1p, and Fpr4p and low abundance proteins are retained in the mother
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