Pyrazole derivatives R 0180 Fragment-Based Discovery of JAK-2 Inhibitors. -Fragment-based hit identification coupled with crystallographically enabled structure-based drug design can provide potent inhibitors of JAK-2 and its clinically relevant V617F mutant. -(ANTONYSAMY, S.; HIRST*, G.; PARK, F.; SPRENGELER, P.; STAPPENBECK, F.; STEENSMA, R.; WILSON, M.; WONG, M.; Bioorg. Med.
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