The modal chromosome number of 14 has been confirmed in Marmosa mitis by examining 622 metaphase spreads derived from heart and lung cell cultures as well as from direct bone marrow preparations. Nine adult individuals, seven females and two males, were investigated. Preferential Y chromosome elimination was observed in both males. It was found that four of the seven chromosome pairs could be identified morphologically while Q-banding allowed differentiation of all chromosomes. The ASG technique revealed that one X chromosome was consistently heterochromatic.
A 14-year-old mentally retarded boy with congenital malformations of unknown etiology was found to have a de novo apparently balanced reciprocal translocation between chromosomal arms 1q and 13q. There is only one other case where a similar translocation was observed but the breakpoints could be localized only by regions and the individual was not mentally retarded.
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