Background: Feline acromegaly has been reported infrequently in the veterinary literature and current knowledge of this endocrinopathy is based on limited numbers of animals with relatively advanced clinical signs.
Hypothesis: This study was undertaken to screen diabetic cats for the presence of acromegaly.
Animals: Diabetic cats with variable control examined by general practitioners in the United Kingdom.
Methods: Blood samples were screened for the possible presence of acromegaly with basal serum concentrations of insulinlike growth factor 1 (IGF‐1) and, when available, feline growth hormone (fGH). In patients with markedly increased IGF‐1 concentrations intracranial computed tomography (CT) was offered, and in selected cats additional imaging was performed.
Results: IGF‐1 was determined in 184 variably controlled diabetic cats; 59 cats had markedly increased IGF‐1 concentrations (.1,000 ng/mL; reference interval, 208–443 ng/mL). Eighteen cats subsequently were examined, and acromegaly was confirmed in 17 cats. Notable findings included absence of a detectable pituitary mass lesion in some affected cats regardless of whether CT or magnetic resonance imaging (MRI) was used. Hypertension was not found to be a complication in the evaluated cats and respiratory stridor was more prevalent than previously reported.
Conclusions and Clinical Importance: Measurement of IGF‐1, growth hormone (GH), or both is useful in the diagnosis of acromegaly in cats.
The frequencies of isolation and population sizes of Malassezia spp. on skin and at mucosal sites in 16 cats with diabetes mellitus, 20 cats with hyperthyroidism and 8 cats with neoplasia did not vary significantly from those of healthy cats when measured with the use of contact plates and a swab technique. M. pachydermatis was isolated from nine sites in one cat with feline paraneoplastic alopecia and pancreatic adenocarcinoma, two cats with diabetes mellitus and five cats with hyperthyroidism. A polymerase chain reaction-restriction enzyme analysis (PCR-REA) method that differentiated the 11 species of Malassezia spp was used to identify the lipid-dependent isolates that were obtained from two cats with diabetes mellitus, two cats with hyperthyroidism and one cat with multicentric lymphoma. Six isolates had PCR-REA patterns that were indistinguishable from M. slooffiae CBS 7956 and three matched M. nana CBS 9557. Our data suggests that skin and mucosal counts of Malassezia spp. are not routinely increased in cats with diabetes mellitus or hyperthyroidism but we report a further example of an association between feline paraneoplastic alopecia and Malassezia spp. proliferation. To the authors' knowledge, this is the first report of the isolation of M. slooffiae from feline skin.
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