Abstmct-A space-variant interpolation is required to compensate for the migration of signal energy through range resolution cells when processing synthetic aperture radar (SAR) data, using either the classical rangelDoppler (RID) algorithm or related frequency domain techniques. In general, interpolation requires significant computation time, and leads to loss of image quality, especially in the complex image. The new chirp scaling algorithm avoids interpolation, yet performs range cell migration correction accurately. The algorithm requires only complex multiplies and Fourier transforms to implement, is inherently phase preserving, and is suitable for wide-swath, largebeamwidth, and large-squint applications. This paper describes the chirp scaling algorithm, summarizes simulation results, presents imagery processed with the algorithm, and reviews quantitative measures of its performance. Based on quantitative comparison, the chirp scaling algorithm provides image quality equal to or better than the precision rangel Doppler processor. Over the range of parameters tested, image quality results approach the theoretical limit, as defined by the system bandwidth.
Efforts to engineer new materials inspired by biological structures are hampered by the lack of genomic data from many model organisms studied in biomimetic research. Here we show that biomimetic engineering can be accelerated by integrating high-throughput RNA-seq with proteomics and advanced materials characterization. This approach can be applied to a broad range of systems, as we illustrate by investigating diverse high-performance biological materials involved in embryo protection, adhesion and predation. In one example, we rapidly engineer recombinant squid sucker ring teeth proteins into a range of structural and functional materials, including nanopatterned surfaces and photo-cross-linked films that exceed the mechanical properties of most natural and synthetic polymers. Integrating RNA-seq with proteomics and materials science facilitates the molecular characterization of natural materials and the effective translation of their molecular designs into a wide range of bio-inspired materials.
Here we report an efficient CRISPR-Cas9 knock-in strategy to activate silent biosynthetic gene clusters (BGCs) in streptomycetes. We applied this one-step strategy to activate multiple BGCs of different classes in five Streptomyces species and triggered the production of unique metabolites, including a novel pentangular type II polyketide in Streptomyces viridochromogenes. This potentially scalable strategy complements existing activation approaches and facilitates discovery efforts to uncover new compounds with interesting bioactivities.
Abstract-This letter derives the two-dimensional point target spectrum for an arbitrary bistatic synthetic aperture radar configuration. The method described makes use of series reversion, the method of stationary phase, and Fourier transform pairs to derive the point target spectrum. The accuracy of the spectrum is controlled by keeping enough terms in the two series expansions, and is verified with a point target simulation.Index Terms-Bistatic SAR, point target spectrum, SAR simulation, series reversion, synthetic aperture radar (SAR).
Abstract-Bistatic synthetic aperture radar data are more challenging to process than the common monostatic counterparts because the flight geometry is more complicated and the data are usually nonstationary. Whereas time-domain algorithms can handle general bistatic cases, they are very inefficient; therefore, frequency-domain methods are preferred. Several frequencydomain monostatic algorithms have been modified to handle a limited number of bistatic cases, but a general algorithm is sought, which can handle cases such as nonequal platform velocities, nonparallel flight tracks, and high squints. In this paper, we modify the nonlinear chirp scaling (NLCS) algorithm to handle a general case of bistatic data. The key is to use a linear range cell migration correction to reduce the range-azimuth coupling, an NLCS to precondition the data for azimuth compression, and a series expansion to obtain an accurate form of the signal spectrum. The azimuth nonstationarity is handled through the use of invariance regions. Simulations have shown that the modified NLCS algorithm can handle data with more complicated bistatic geometries than the previous algorithms.Index Terms-Bistatic SAR, chirp scaling, perturbation function, point target response, range cell migration (RCM) correction (RCMC), secondary range compression (SRC), synthetic aperture radar (SAR).
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