All cancer patients should be evaluated for constipation [V, B]. In patients with advanced cancer, underlying causative factors for Table 3. Key factors in the assessment of constipation Date of last defaecation Frequency of bowel movements Consistency of the stool Recent changes in bowel patterns Urge to defaecate (presence or absence) Sensation of evacuation (complete or incomplete) Faecal incontinence (presence or absence, including rectal leakage) Evidence of blood or mucus on defaecation Current and previous laxative use Need for digital manipulation to assist or manage evacuation Annals of Oncology

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The results of this randomized phase II study showed significantly higher PSA decline < or = 50% and longer times to progression in HRPC patients receiving DEP-based chemotherapy than MP, and that DEP could be proposed in this setting.