Key PointsQuestionIs an early, high transfusion ratio of fresh frozen plasma to packed red blood cells associated with 30-day mortality in patients with severe bleeding after trauma?FindingsIn this cohort study of 897 patients in the French national trauma registry Traumabase, an early, high transfusion ratio of fresh frozen plasma to packed red blood cells was associated with increased 30-day mortality in patients with severe bleeding after trauma.MeaningThese results support an early, high transfusion ratio of fresh frozen plasma to packed red blood cells as part of the hemostatic resuscitation strategy in severe trauma.
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