Introduction:Machine learning research into automated dementia diagnosis is becoming increasingly popular but so far has had limited clinical impact. A key challenge is building robust and generalizable models that generate decisions that can be reliably explained. Some models are designed to be inherently "interpretable," whereas post hoc "explainability" methods can be used for other models.Methods: Here we sought to summarize the state-of-the-art of interpretable machine learning for dementia. Results:We identified 92 studies using PubMed, Web of Science, and Scopus. Studies demonstrate promising classification performance but vary in their validation procedures and reporting standards and rely heavily on popular data sets.Discussion: Future work should incorporate clinicians to validate explanation methods and make conclusive inferences about dementia-related disease pathology. Critically analyzing model explanations also requires an understanding of the interpretability methods itself. Patient-specific explanations are also required to demonstrate the benefit of interpretable machine learning in clinical practice.
Finding an object amongst a cluttered visual scene is an everyday task for humans but presents a fundamental challenge to computational models performing this feat. Previous attempts to model efficient visual search have focused on locating targets as swiftly as possible, but so far have not considered balancing the costs of lengthy searches against the costs of making errors. Here, we propose a neuro-inspired model of visual search that offers an attention-based control mechanism for this speed-accuracy trade-off. The model combines a goal-based fixation policy, which captures human-like behaviour on a simple visual search task, with a deep neural network that carries out the target detection step. The neural network is patched with a target-based feature attention model previously applied to standalone classification tasks. In contrast to image classification, visual search introduces a time component, which places an additional demand on the model to minimise the time cost of the search whilst also maintaining acceptable accuracy. The proposed model balances these two costs by modulating the attentional strength given to characteristic features of the target class, thereby minimising an associated cost function. The model offers a method for optimising the costs of visual search and demonstrates the value of a decision theoretic approach to modelling more complex visual tasks involving attention.
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