Seven upper‐rim fully tethered cyclodextrins (URFT‐CDs) have been synthesised in a good average coupling yield using the one‐step “phosphine imide” approach and their metal complexation behaviour with lanthanides and transition metals was explored. We observed that the A‐TE‐E light conversion process (antennae effect) occurs in the URFT‐CD lanthanide complexes. A molecular redox switch based on the corresponding iron complexes is also reported. A reversible intramolecular translocation of the FeII and FeIII ions, between two distinct binding cavities has been monitored spectroscopically and achieved by chemical triggering. Finally, a negative allosteric control of ion recognition through the formation of a CD pseudocryptand is discussed.
The formation of supramolecular host-guest complexes is a very useful and widely employed tool in chemistry. However, supramolecular chemistry in non-conventional solvents such as supercritical carbon dioxide (scCO2 ), one of the most promising sustainable solvents, is still in its infancy. In this work, we explored a successful route to the development of green processes in supercritical CO2 by combining a theoretical approach with experiments. We were able to synthesize and characterize an inclusion complex between a polar aromatic molecule (benzoic acid) and peracetylated-β-cyclodextrin, which is soluble in the supercritical medium. This finding opens the way to wide, environmental friendly, applications of scCO2 in many areas of chemistry, including supramolecular synthesis, reactivity and catalysis, micro and nano-particle formation, molecular recognition, as well as enhanced extraction processes with increased selectivity.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which caused the COVID-19 pandemic spreading around the world from late 2019, served as a ruthless reminder of the threat viruses pose to global public health. The synthesis of new antiviral drugs, as well as repurposing existing products, is a long-term ongoing process which has challenged the scientific community. One solution could be an effective, accessible, and rapidly available antiviral treatment based on phototherapy (PT). PT has been used to treat several diseases, and relies on the absorption of light by endogenous molecules or exogenous photosensitizers (PS). PT has often been used in cancer treatment and prophylaxis, and as a complement to established chemotherapy and immunotherapy in combined therapeutic strategy. Besides significant applications in anticancer treatment, studies have demonstrated the beneficial impact of PT on respiratory, systemic, emerging, and oncogenic viral infections. The aim of this review was to highlight the potential of PT to combat viral infections by summarizing current progress in photodynamic, photothermal, and photoacoustic approaches. Attention is drawn to the virucidal effect of PT on systemic viruses such as the human immunodeficiency virus and human herpes viruses, including the causative agent of Kaposi sarcoma, human herpes virus (HHV8). PT has good potential for disinfection in anti-norovirus research and against pandemic viruses like SARS-CoV-2.
Supercritical carbon dioxide, an environmentally friendly medium, is promising as an alternative to traditional organic solvents. However, polar molecules and high molar mass compounds are often poorly soluble in supercritical carbon dioxide. The first host–guest complex obtained in such a solvent is discussed herein, together with an analysis of the driving forces for the formation of supramolecular structures and suggestions for possible applications to fix solubility issues. More information can be found in the Full Paper by F. Ingrosso, A. Marsura, M. F. Ruiz‐López et al. on page 2972 ff.
Mots clés : modélisation, environnement, développement durable, agriculture, changement de pratique Key words: modeling, environment, sustainable development, agriculture, change in practice Résumé : L'intervention ergonomique dans le champ du développement durable requiert la prise en compte d'un environnement dépassant largement l'environnement de travail afin d'y intégrer des composants supra relevant de dimensions environnementale, sociale, économique, législative, etc. pouvant impacter ou être impacté par l'activité. Les ergonomes et psychologues ergonomes sont alors conduits à développer des cadres de modélisation permettant d'appréhender et de rendre davantage intelligible cet environnement complexe. L'étude sur laquelle nous nous basons ici s'inscrit dans ce cadre et vise l'identification des freins et leviers à la mise en place d'une nouvelle pratique en matière de traitement antifongique pour la filière orge-malt-bière. Pour cette investigation, nous nous référons notamment à la modélisation de Thatcher et Yewo (2016). L'enjeu est de présenter le processus de recueil et d'analyse sousjacente à la modélisation et de poursuivre par une réflexion quant à l'emploi de ces formes de modélisation au cours d'un processus d'intervention.
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