Objective: Identify echocardiographic parameters at p4 day postnatal that predict the subsequent need for closure of a clinically significant patent ductus arteriosus (sPDA) in extremely-low-birth-weight neonates (ELBW).Study Design: Serial echocardiograms obtained in 115 ELBW at p10 day postnatal were examined to estimate PDA size using the PDA:left pulmonary artery (LPA) diameter ratio: X1 indicated a large PDA, <1 but X0.5 moderate, and <0.5 small. Sensitivity, specificity, and positive predictive values (PPV) were determined for ELBW <27 weeks and X27 weeks gestational age.Result: Neonates with moderate to large PDA at p4 day had 15-times greater likelihood of requiring treatment for sPDA than those with a small PDA (95% confidence interval (CI): 5.6-41). Sensitivity, specificity and PPV of the PDA:LPA at <27 weeks was 80, 86 and 92%, respectively. Conclusion:A moderate to large PDA determined from the PDA:LPA ratio at p4 day postnatal identifies neonates <27 week gestation who subsequently require closure of a PDA.

patients admitted to the AICU, 30.5% died, 69.0% were transferred to another unit, and 0.5% were discharged. Conclusion The findings showed high compliance of AST at admission but low compliance at discharge, which needs further enforcement. Although the acquisition of CRKP was only 3.4%, it represents adding almost double (1.8) new cases of CRKP to the admission level. Future research is required to assess the impact of AST on the burden of healthcare-associated infections.