The object of this study is to evaluate the efficacy of a high dose of carboplatin in 20 patients operated on for high grade glioma (Group A) compared with a matched control (Group B) treated with BCNU administered after radiotherapy. The toxicity profile has been evaluated during the therapy. The survival of patients entering this study was measured in terms of months: the mean survival time was 10.45 months and the median 11.0 months in the group treated with carboplatin (8 patients are still alive); the 18-month survival rate was 10%. The mean survival time of the control group was 9.85 months and the median 10.5 months; no patients are still alive and the 18-month survival rate was 0%. On the basis of our phase II clinical study, we could conclude that i.v. administration of high-doses of carboplatin in high grade gliomas is generally well tolerated and the results are better than those of a matched control treated with 1-2 courses of BCNU (low-dose). The adjuvant treatment and the role of carboplatin in the therapy of high grade gliomas is discussed.
What mitigates the relationship between need for cognitive closure and prejudice against migrants? Addressing this question, we explored how national identification, endorsing binding moral foundations and the perception of threat mediate the relationship between need for cognitive closure and prejudice against migrants in Malta. It was hypothesized that individuals with a high need for cognitive closure are more prone to identify with being Maltese and more probable to endorse binding moral foundations and perceive high threat from migrants, leading to a more prejudiced attitude towards migrants living in Malta. Two hundred and twentytwo individuals participated in this quantitative study.Results from this study showed that national identification, binding moral foundations and perceived threat mediate the relationship between need for cognitive closure and prejudice against migrants. The implications of the findings for theories about how need for cognitive closure contributes to increased prejudiced attitude in native population is discussed. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
A 44 year-old man with subcutaneous meningioma and rare combination of spinal lesions, consisting of dermal sinus and lipoma of the filum terminale. The literature concerning the subcutaneous meningioma is reviewed and the embryogenesis of these lesions is discussed.
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