This case report follows a 42-year-old female patient who underwent a routine screening mammogram. The patient was found to have a 50 mm benign subareolar mass in the right breast. However, because benign imaging findings do not preclude malignancy, the patient was recommended to undergo a biopsy for confirmation. Subsequent imaging and core needle biopsy established a benign lesion consistent with stromal fibrosis with underlying fibroadenomatous changes. The benign imaging and histological findings of the breast mass were concordant. The patient was recommended yearly mammograms and continued observation. This case report highlights the importance of radiopathological concordance in patients found to have benign imaging findings on screening mammograms.
Spontaneously resolving breast calcification on mammography is a rare radiologic finding. This phenomenon is defined by a decrease in number and/or prominence of breast calcifications on mammogram when compared to prior imaging. The significance of resolving breast calcifications remains unclear, but they have been reported in cases of malignancy. In current literature, patients whose imaging illustrated a decrease in calcifications usually had other concomitant breast complaints. We are presenting a case of invasive ductal carcinoma, in which the patient was asymptomatic on physical examination. Spontaneously resolving breast calcification and lymphadenopathy were the only abnormal findings on screening mammogram.
Male breast cancer (MBC) is a rare disease that accounts for less than one percent of all breast cancers. The association between
BRCA1
and
BRCA2
mutations and MBC has been well-established; recent data suggest that CHEK2 1100delC heterozygosity is also associated with an increased risk of MBC. Herein, we present the case of a 47-year-old male who was initially diagnosed with bilateral symmetric gynecomastia on a diagnostic mammogram performed for right breast palpable lump. Sixteen months after his diagnosis of gynecomastia, he presented with enlarging right breast palpable lumps and underwent a diagnostic mammogram and breast ultrasound. Ultrasound-guided biopsies were performed on the right breast mass and axillary lymphadenopathy. Pathology revealed right breast invasive ductal carcinoma (IDC) and right axillary metastatic lymphadenopathy. Subsequent genetic testing found CHEK2*1100delC mutation. This case report focuses on the presentation, diagnosis, and management of breast cancer, as well as long-term cancer screening in the setting of
CHEK2
mutation in a relatively young male patient.
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