Deep brain stimulator (DBS) implant surgery is considered a breakthrough in the
treatment of Parkinson's disease, especially in cases where motor symptoms
cannot be controlled through conventional drug treatment. Its benefits have been
studied extensively in the literature, particularly in relation to motor
symptoms. However, the disease's cognitive aspects have been studied to a lesser
extent.ObjectiveThis systematic review aims to assess the effects of DBS surgery on motor and
cognitive symptoms in patients with Parkinson's disease.MethodsThe search strategy included MEDLINE, LILACs, SCIELO and the Cochrane
Library. Randomized clinical trials with DBS surgical intervention and
Parkinson's disease were included. Of the 178 studies identified, 19 met the
eligibility criteria. These studies were descriptively analyzed as regards
to their results.ResultsControl of motor symptoms, as assessed by the UPDRS Part III scale, was found
in all of the studies, pointing to great interest in this outcome and
demonstrating an advantage of DBS over conventional drug treatment.
Regarding cognitive aspects, heterogeneity in the choice of subjects studied
and the use of different assessment tools for each was evident, hampering
comparisons and leading to inconclusive results.ConclusionThis review provides a broad overview of the effects of DBS on Parkinson's
disease symptoms. However, it is suggested that future studies be conducted
to establish a gold-standard protocol for neuropsychological assessment,
thereby enabling data comparison and more consistent conclusions.
BackgroundParkinson's disease (PD) shows symptoms involving motor and non-motor
complications, including cognitive and behavioral changes, such changes
might to contraindicate deep brain stimulation surgery (DBS).ObjectiveThe aim of study was to investigate the neuropsychological profile of
patients with PD in a waiting list for DBS.MethodsThe neuropsychological evaluation was held in 30 patients of the ISCMPA
Movement Disorders Clinic, with surgical indication based on the criteria of
the responsible neurologists, in the period of 12 months. Instruments used:
MMSE, FAB, MoCA, BDI, Semantic Verbal Fluency, PDQ-39, PDSS; and the UPDRS
and Hoehn-Yahr scale.ResultsThe patients were mostly male (66.7%) with a mean age of 59.37 (SD 10.60) and
disease duration 9.33 (SD 4.08). There was cognitive impairment in 56.7% of
patients by FAB and 76.7% by MoCA.ConclusionEven in the earliest stages of the disease, there is the incidence of
non-motor symptoms, especially in those subjects who had an early onset of
the disease.
Objetivo: apresentar a estimativa de precisão e as evidências de validade baseada nas relações com variáveis externas do Teste de Triagem do Desenvolvimento Infantil – Habilidades Motoras (TDI-HM). Esse instrumento compõe uma bateria multidisciplinar de triagem que avalia, além das Habilidades Motoras, a Linguagem e as Funções Executivas de crianças em fase de escolarização inicial. Métodos: a amostra do estudo foi composta por 382 alunos (6 a 8 anos), matriculados em escolas públicas de Porto Alegre, Rio Grande do Sul, Brasil. As variáveis do desenvolvimento motor foram rastreadas pelo instrumento elaborado (TDI-HM) e pelo teste Escala de Desenvolvimento Motor (EDM). Resultados: a análise de fidedignidade do TDI-HM indicou boa consistência interna do total de 16 itens do instrumento (Alfa = 0,76). A consistência interna (Alfa) das dimensões avaliadas em separado apresentou: motricidade ampla = 0,84 (6 itens), equilíbrio = 0,67 (4 itens), motricidade fina = 0,70 (6 itens). Comparando desempenho na escala por idade, os resultados indicaram que houve diferença significativa das médias por idade tanto no quociente motor geral – 6 anos, 110,50 (DP 7,86); 7 anos 100,21(DP 5,57) e 8 anos 89,85 (4,28) – quanto por dimensão. Conclusões: os resultados apresentaram evidências de que o TDI-HM tem potencial para verificar se o desempenho das HM está de acordo com os parâmetros esperados para a idade. Considera-se que, na sequência dos estudos, isso possa contribuir para o uso em pesquisas, em práticas clínicas e escolares relacionadas com o desenvolvimento motor em crianças no Brasil.
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