Adanya komplikasi Penyakit Ginjal Kronis (PGK) dapat meningkatkan risiko morbiditas dan mortalitas pasien Diabetes Melitus Tipe 2 (DMT2). Kemunculan komorbid hipertensi dan dislipidemia meningkatkan risiko komplikasi makrovaskular dan mikrovaskular serta menambah jumlah jenis penggunaan obat. Manajemen terhadap komorbid tersebut sangat penting untuk mencegah kejadian kardiovaskular dan meminimalkan kerusakan ginjal. Penelitian ini bertujuan mengevaluasi profil terapi antihipertensi dan antihiperlipidemia terhadap fungsi ginjal pasien DMT2 dengan komplikasi PGK di RSUP Dr. Hasan Sadikin. Penelitian dilakukan menggunakan metode kohort prospektif dengan teknik consecutive sampling dan diperoleh sebanyak 37 pasien. Data kadar kreatinin serum, ureum dan nilai eGFR yang diperoleh dari Desember 2017 sampai Februari 2018 menjadi dasar analisis dalam penelitian ini. Hasil penelitian menunjukkan bahwa terdapat penurunan bermakna dari nilai kreatinin serum (p<0,05) dan ureum (p<0,05) serta peningkatan bermakna nilai eGFR (p<0,05) selama tiga bulan penelitian. Berdasarkan hasil penelitian dapat disimpulkan bahwa profil terapi antihipertensi dan antihiperlipidemia yang digunakan dapat mengendalikan fungsi ginjal pasien DMT2 dengan komplikasi PGK selama tiga bulan penelitian berdasarkan kadar kreatinin serum, ureum dan nilai eGFR.
Effective management of diabetes therapy is a major challenge in the management of chronic conditions that are accompanied by comorbidities like dyslipidemia. The potential of unwanted events or Drug-Related Problems (DRPs) increases the emergence of comorbidities. This study aims to identify the correlation between the incidence of DRPs and clinical outcomes in patients with type 2 diabetes mellitus with dyslipidemia at Central Hospital Dr. M. Djamil Padang. The study was conducted by prospective method that used purposive sampling technique with 25 inpatients. Identification of DRPs used Pharmaceutical Care Network Europe (PCNE) version 8.01. Inclusion criterias were type 2 diabetes mellitus patient with dyslipidemia and also patients were prescribed at least one of antidiabetic or anti dyslipidemia drug. The results showed that there were several types of DRPs consist of inappropriate drug combinations (32%), untreated indications (20%), inappropriate timing and/or dosing intervals (12%), and too short duration (8 %). Statistical analysis showed that there was not significant correlation (p>0.05) between the incidence of DRPs and clinical outcomes in type 2 diabetes mellitus patients with dyslipidemia at Central Hospital Dr.
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