Well water could be a stable source of drinking water. Recently, the use of well water as drinking water has been encouraged in developing countries. However, many kinds of disorders caused by toxic elements in well drinking water have been reported. It is our urgent task to resolve the global issue of element-originating diseases. In this review article, our multidisciplinary approaches focusing on oncogenic toxicities and disturbances of sensory organs (skin and ear) induced by arsenic and barium are introduced. First, our environmental monitoring in developing countries in Asia showed elevated concentrations of arsenic and barium in well drinking water. Then our experimental studies in mice and our epidemiological studies in humans showed arsenic-mediated increased risks of hyperpigmented skin and hearing loss with partial elucidation of their mechanisms. Our experimental studies using cultured cells with focus on the expression and activity levels of intracellular signal transduction molecules such as c-SRC, c-RET, and oncogenic RET showed risks for malignant transformation and/or progression arose from arsenic and barium. Finally, our original hydrotalcite-like compound was proposed as a novel remediation system to effectively remove arsenic and barium from well drinking water. Hopefully, comprehensive studies consisting of (1) environmental monitoring, (2) health risk assessments, and (3) remediation will be expanded in the field of environmental health to prevent various disorders caused by environmental factors including toxic elements in drinking water.

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Particulate matter (PM) is an air pollutant that has an impact on public health, especially in an urban area. The objective of this study was to analyze the personal concentration of PM2.5 and its composition among police working in the roadside area in Jakarta. PM measurement has done to the policeman that controlled traffic on four near highway locations in Jakarta. Sioutas impactor, Leland Legacy personal pump, and quartz fiber filter were chosen to measure the fine particles. Each PM was measured for 8-hour period. PM concentration was analyzed by the gravimetric method while tracing element and black carbon in PM0.25 by energy dispersive X-ray fluorescence (EDXRF) and EEL Smoke Stain Reflectometer. As a result, near highway PM2.5 concentration in Jakarta during weekdays and weekends measurement are 92.18 ± 10.66 μg/m3, and 78.09 ± 11.61 μg/m3. S, K, Fe, Ca, Zn, and Pb are major elements found in all locations. The black carbon concentration in all location was 17 ± 5.7 μg/m3. A high concentration of fine particles, a traffic-related trace element in PM0.25, and black carbon are showed that traffic-related source is the major contributor to a high level of fine particulate matter at near highway locations in Jakarta. The weekday's concentration of PM2.5 and PM0.25 among Jakarta Policemen was higher than in the weekend concentration. A particle with size of less than 0.25 µm dominated the fine particles concentration. Further researcher is expected to see the difference in the effects of traffic-related particulate matter exposure between traffic policeman and police who work at office.

Diabetes melitus merupakan suatu penyakit dengan adanya gangguan sekresi insulin baik karena penurunan sensitifitas maupun kerusakan pada sel beta. Tujuan penelitian ini adalah membuktikan ekstrak daun petai cina (Leucaena leucocephala (Lam.) de Wit) memiliki aktivitas menurunkan kadar gula darah mencit hiperglikemik pada dosis yang efektif. Penelitian antihiperglikemik ini menggunakan mencit putih sebanyak 30 ekor. Pengujian aktivitas antihiperglikemik dilakukan pada 6 kelompok perlakuan yaitu kelompok I (kontrol normal), kelompok II (kontrol negatif, induksi aloksan 200 mg/kg BB dan akuades), kelompok III (induksi aloksan dan glibenklamida 10 mg/kg BB), kelompok IV (induksi aloksan dan ekstrak daun petai cina 200 mg/kg BB), kelompok V (induksi aloksan dan ekstrak daun petai cina 400 mg/kg BB), kelompok VI (induksi aloksan dan ekstrak daun petai cina 300 mg/kg BB). Semua kelompok perlakuan diberikan perlakuan tersebut selama 14 hari dan dilakukan pengukuran kadar gula darah pada hari ke-0, 3, 10, dan 17. Aktivitas antihiperglikemik ekstrak daun petai cina ditunjukkan dengan cara menghitung daya hipoglikemik masing-masing perlakuan. Hasil penelitian menunjukkan bahwa ekstrak etanol daun petai cina mempunyai aktivitas antihiperglikemik pada mencit yang diinduksi aloksan. Pada dosis uji ekstrak etanol daun petai cina 600 mg/kg BB mempunyai aktivitas antihiperglikemik yang efektif dibanding dengan dosis 400 mg/kg BB dan 200 mg/kg BB yang sebanding dengan kelompok kontrol positif.

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ABSTRAKPasien usia lanjut mempunyai berbagai macam komorbiditas dengan berbagai macam pengobatan yang diresepkan, oleh karena itu angka Adverse Drug Events meningkat. Hal ini disebabkan oleh perubahan fisiologi yang terkait pada usia dan komposisi tubuh, dampak proses penuaan yang bersifat universal berupa penurunan fungsi sel, jaringan dan organ yang bersifat progresif dan bertahap yang mempengaruhi kondisi dan respon obat didalam tubuh pasien usia lanjut. Kriteria STOPP memuat obat-obatan yang tidak tepat diberikan pada pasien usia lanjut.Penelitian yang dilakukan adalah analitik retrospektif, yang terdiri dari dua kelompok penelitian yaitu kelompok pasien yang tepat menjalani pengobatan dan kelompok pasien yang tidak tepat menjalani pengobatan. Data penelitian yang diambil adalah data pasien geriatri.Pengobatan berdasarkan kriteria STOPP dari 70 pasien geriatri terdiri dari 33 pasien laki-laki (47%) dan 37 pasien perempuan (53%). Sebanyak 51 pasien (73%) mendapatkan pengobatan tepat, sedangkan 19 pasien (27%) mendapatkan pengobatan tidak tepat. Pengobatan yang digunakan meliputi obat sistem jantung dan pembuluh darah, antiplatelet dan antikoagulan, obat sistem saraf pusat dan psikotropika, sistem ginjal, sistem gastrointestinal, sistem pernafasan, sistem otot dan rangka, sistem endokrin, dan obat analgetika. Kelompok yang mendapatkan pengobatan tidak tepat memiliki kejadian ESO diantaranya jantung berdebar, mual muntah dan konstipasi.

No abstract

COVID-19 has affected all aspects of human life so far. From the outset of the pandemic, preventing the spread of COVID-19 through the observance of health protocols, especially the use of sanitizers and disinfectants was given more attention. Despite the effectiveness of disinfection chemicals in controlling and preventing COVID-19, there are critical concerns about their adverse effects on human health. This study aims to assess the health effects of sanitizers and disinfectants on a global scale. A total of 91,056 participants from 154 countries participated in this cross-sectional study. Information on the use of sanitizers and disinfectants and health was collected using an electronic questionnaire, which was translated into 26 languages via web-based platforms. The findings of this study suggest that detergents, alcohol-based substances, and chlorinated compounds emerged as the most prevalent chemical agents compared to other sanitizers and disinfectants examined. Most frequently reported health issues include skin effects and respiratory effects. The Chi-square test showed a significant association between chlorinated compounds (sodium hypochlorite and per-chlorine) with all possible health effects under investigation ( p -value <0.001). Examination of risk factors based on multivariate logistic regression analysis showed that alcohols and alcohols-based materials were associated with skin effects (OR, 1.98; 95%CI, 1.87–2.09), per-chlorine was associated with eye effects (OR, 1.83; 95%CI, 1.74–1.93), and highly likely with itching and throat irritation (OR, 2.00; 95%CI, 1.90–2.11). Furthermore, formaldehyde was associated with a higher prevalence of neurological effects (OR, 2.17; 95%CI, 1.92–2.44). Furthermore, formaldehyde was associated with a higher prevalence of neurological effects (OR, 2.17; 95%CI, 1.92–2.44). The use of sodium hypochlorite and per-chlorine also had a high chance of having respiratory effects. The findings of the current study suggest that health authorities need to implement more awareness programs about the side effects of using sanitizers and disinfectants during viral epidemics especially when they are used or overused. Supplementary Information The online version contains supplementary material available at 10.1007/s11356-023-27197-6.