The authors used a three-layer approach to correlate the appearance of the capsule and ligaments of the medial side of the knee on magnetic resonance (MR) images with corresponding anatomic slices. MR images of six fresh cadaveric specimens were obtained by using a proton-density-weighted fast spin-echo sequence with a 256 x 512 matrix. Specimens were frozen and sliced with a band saw into 3. 0-mm-thick sections that corresponded to the MR images. Three layers were depicted on both anatomic slices and MR images. Layer 1 consisted of the deep crural fascia; layer 2, the superficial portion of the medial collateral ligament (MCL); and layer 3, the capsule, the deep portion of the MCL, the meniscofemoral and meniscotibial extensions of the deep portion of the MCL, and the patellomeniscal ligament. Along the anterior aspect of the medial side of the knee, layer 1 was fused with layer 2; along the posterior aspect of the knee, layer 2 was fused with layer 3.

Diffusion weighted imaging sequences are now widely available on Magnetic Resonance Imaging (MRI) scanners. Diffusion Tensor Imaging (DTI) of the brain is able to show white matter tracts and is now commonly used in human medicine to study brain anatomy, tumors, structural pathways,. . . The purpose of this study was to show the interest of DTI to reveal the white matter fibers in the dogs' brain. DTI MR Images for this study were obtained with a 3 T system of 4 dogs euthanized for other reasons than neurological disorders. Combined fractional anisotropic (FA) and directional maps were obtained in the first 2 hours after death. The heads were amputated immediately after scanning and stored in 10% formalin until preparation for dissection. An experienced anatomist tracked white matter tracts with clinical relevance using the scanner software. The selected tracts were volume rendered and correlated with gross dissection. Using DTI we were able to track relevant neurological connections, such as the corticospinal tract, the optic and the cerebellar tract. The three dimensional anatomy is better presented using modern visualization techniques. DTI seems to be a valuable tool in order to present clinically relevant white matter tracts to neurological clinicians and researchers. Anat Rec, 296:340-349, 2013. V C 2013 Wiley Periodicals, Inc.Key words: brain; diffusion tensor imaging; dog; anatomy Since a few years, Magnetic Resonance Imaging is a reference technique for imaging the brain in different planes (sagittal, transversal, coronal) and the use of 1,5T to 7T MRI allows more and more accurate and detailed visualization of white matter localization than conventional CT-Scan and X-Ray (Van Thielen et al., 2010). However, an atlas of all the white matter tracts would be particularly useful for providing detailed anatomical data that is not available in studies based on conventional MRI data (Lawes et al., 2008). So we

Acute studies suggested a therapeutic benefit for fundus-relaxing drugs in functional dyspepsia (FD) with visceral hypersensitivity (VH) to gastric distention or impaired accommodation (IA), but long-term studies are lacking. R-137696 is a serotonin-1A (5-HT(1A)) receptor agonist which relaxes the proximal stomach in man. Our aim was to investigate the influence of R-137696 on symptoms in FD with VH or IA. Randomized, double-blind, placebo-controlled, parallel group study of 4 weeks R-137696 2 mg t.i.d. in FD with VH or IA. Symptoms were assessed using the patient assessment of upper gastrointestinal symptom severity index (PAGI-SYM) total score and individual symptom subscales. Barostat studies were performed before and after 4 weeks of treatment. Fifty-three patients (33 VH and 20 IA), 18 men, mean age 40 +/- 13 years were recruited. Twenty-four received placebo and 29 received R-137696. In VH patients, both placebo and R-137696 improved total symptom scores, with a tendency for superiority of placebo (-1.12 vs-0.51, P = 0.07). Placebo was superior for the subscales of early satiety, bloating, fullness and discomfort (all P < 0.05). In IA, both placebo and R-137696 had no significant influence on total or individual symptom scores (-0.08 and -0.27). In VH, both placebo and R-137696 increased the discomfort volume, without a statistical difference between both arms (+120 and +164 mL). In IA, both placebo and R-137696 enhanced accommodation, without a statistical difference between both (+77 and +159 mL). Adverse events were similar for drug and placebo. A 4-week administration of the fundus-relaxing 5-HT(1A) agonist R-137696 failed to significantly improve symptoms, VH or gastric accommodation compared to placebo.

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