Polymer-drug conjugates are currently being more widely investigated for the treatment of hypertension. In view of the above, in the first stage of our work, we used nontoxic β-cyclodextrin (β-CD) as effective, simple, inexpensive, and safe for the human body initiator for the synthesis of biocompatible and biodegradable functionalized polymers suitable for the medical and pharmaceutical applications. The obtained polymeric products were synthesized through a ring-opening polymerization (ROP) of ε-caprolactone (CL), d,l-, and l,l-lactide (LA and LLA). The chemical structures of synthesized materials were elucidated based on 1H NMR and solid-state carbon-13 cross-polarization/magic angle spinning nuclear magnetic resonance (13C CP/MAS NMR) analysis, while the incorporation of β-CD molecule into the polymer chain was confirmed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Furthermore, molecular modeling has been applied to investigate the intrachain rigidities and chain architectures for several representative structures. The obtained and thoroughly characterized branched matrices were then used to generate the first β-cyclodextrin/biodegradable polymer/β-blocker conjugate through the successful conjugation of pindolol. The conjugates were fabricated by carbodiimide-mediated coupling reaction. The branched biodegradable materials released the drug in vitro in a sustained manner and without “burst release” and thus have the ability to treat different heart diseases.
Paklitaksel (PTX) jest naturalnym lekiem przeciwnowotworowym - alkaloidem terpenowym z grupy taksanów stosowanym w terapii raka niedrobnokomórkowego płuc, nowotworów jajnika i piersi oraz mięsaka Kaposiego. PTX daje bardzo dobry efekt terapeutyczny zarówno w monoterapii, jak i w połączeniu z innymi lekami przeciwnowotworowymi. Po raz pierwszy został on wyizolowany z kory cisa krótkolistnego (Taxus brevifolia) i wprowadzony do lecznictwa pod nazwą „Taxol” przez amerykańską firmę biofarmaceutyczną Bristol-Myers Squibb. Podstawowy mechanizm działania PTX polega na blokowaniu cyklu komórkowego w fazie G2/M poprzez hamowanie depolimeryzacji mikrotubul, co uniemożliwia przebieg mitozy. Ponadto PTX może powodować nekrozę komórki poprzez podziały wielobiegunowe i nieprawidłową segregację chromosomów.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.