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Thrombolysis with recombinant streptokinase is efficacious and safe for the treatment of prosthetic heart valve thrombosis. It does not contraindicate surgical treatment if there is no total response, because patient goes to surgery in better hemodynamic conditions with lower risk. Nowadays it can be considered as first-line treatment in all patients with prosthetic heart valve thrombosis regardless of functional class unless specific contraindications exist.

To cite this article: Castilho FM, de Sousa MR, Mendonc ßa ALP, Ribeiro ALP, C aceres-L origa FM. Thrombolytic therapy or surgery for valve prosthesis thrombosis: systematic review and meta-analysis.

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