Bronchial carcinoid tumors (BCTs) are an uncommon group of lung tumors. They commonly affect the young adults and the middle aged, the same age group affected by other more common chronic lung conditions such as pulmonary tuberculosis. Diagnosis is commonly missed or delayed due to a low index of suspicion. Surgery is the mainstay of treatment with an excellent outcome. There are many reports of this rare group of tumors in the Western and Asian regions. The only report around our sub-region is a post mortem report of an atypical variant. We wish to report a case of the typical variant and increase our index of suspicion. A 25-year-old male presented with a 4 years history of cough and haemoptysis. He was repeatedly treated for bronchial asthma and pulmonary tuberculosis with no improvement of symptoms. Chest X-ray and chest computed tomography scan revealed a left upper lobe tumor. Histology reported a typical variant of BCT which was confirmed by immunohistochemistry. He had a left upper lobectomy and has done excellently well thereafter. A high index of suspicion is needed to reduce the risk of missing or delaying the diagnosis.
Primary synovial sarcoma is a very rare tumor of the mediastinum, which is unreported in the entire subcontinent of West Africa, and presents daunting challenges from diagnosis to management with lack of standard management strategies. We present a case of primary monophasic synovial sarcoma of the anterior mediastinum, in a 22-year-old Nigerian lady who presented with cough, chest pain, and pleural effusion. Chest X-ray (CXR) and computed tomography on admission showed a left-sided huge mass in the left anterior mediastinum with no metastasis to the contralateral pleural cavity. Complete resection of the mediastinal tumor was done and histologic and immunohistochemical analyses confirmed a diagnosis of monophasic synovial sarcoma. However, 10 months postoperation she represented with chest pain, productive cough and a repeat CXR showed multiple left pulmonary nodules. She received two cycles of docetaxel and gemcitabine chemotherapy, but declined further treatment until her demise 8 months later.
Plants and plant extracts have been found very useful for purposes of treatment of disease among other benefits.Cannabis sativa is one of such plants whose effect on wound healing, haemostatic and biochemical profile was studied using albino wistar rats. Canabis sativa is an illicit drug with proven anti-inflammatory, analgesic and anti-diarrhea activities. This present study is aimed at ascertaining the impact of prolonged administration of cannabis sativa on haemostatic mechanism, cutaneous wound healing and biochemical profile of albino wistar rats. Forty (40) albino wistar rats weighing 180-200g were acclimatized in the animal house for 7 days. After this, they were divided into five groups respectively. Group A was the control male rats (6), Group B was the female control rats (6), Group C (10) was the male test rats and Group D (10) was the femaletest rats and Group E (8) for incision. Group C and D male rats were fed for 30 days with aqueous extract of Canabis sativa before 5.0ml of blood sample was collected from the animals for cardiac puncture and placed in haemogram bottles (EDTA and sodium citrate) for haemostatic analysis and in plain bottles for liver function tests while Group E rats were those with incision made in their skin that received topical treatment of aqueous extract of cannabis sativa and injection for 5days.Results from the study showed that the extract significantly increased the total and conjugated bilirubin, (P<0.05), liver enzymes; Alkaline Phosphatase (ALP), Aspartate Transaminase (AST) and Alanine Transaminase (ALT), Haemoglobin concentrations, Packed cell volume, platelet count and white blood cell count. The bleeding and clotting times,ProthrombintimeandPartialthromboplastin times were shortened compared to their corresponding controls. The incised wounds haled within shorter days than those in control rats. The alterations in the results are manifestation of mild hepatorenal toxicity and anti-hypercholestrolemic effect. These liver enzymes are highly affected by cannabis sativa in females than in males.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.