Objective: To compare the sensitivity and specificity of Squamous Cell Carcinoma (SCC) and Vascular Endothelial Growth Factor (VEGF) levels to assess the response of radiation therapy. Method: The study was conducted by the method of analytic observational cohort study in 24 patients with cervical cancer stage II-B and III-B in RSCM that met inclusion criteria. Examination of VEGF and SCC in serum samples was performed in the Prodia Laboratory Jakarta. The examination was conducted twice before and after radiation therapy. The subjects were treated by radiation therapy/chemoradiation according to standard procedures. After the completion of radiation was declared, the response of radiation therapy was conducted by clinical assessment. Result: Of the 24 subjects, we obtained a mean level of SCC pre-radiation was 23.43 ± 5.84 ng/ml and post-radiation was 2.19 ± 0.68 ng/ml. The mean VEGF pre-radiation was 790.41 ± 111.06 pg/ml and post-radiation was 497.47 ± 79.26 pg/ml. ROC curves of each tumor marker obtained SCC pre-radiation AUC 40%, p 0.53 (CI 0.18-0.68) and SCC post-radiation AUC 48.1%, p 0.91 (CI 0.21-0,75) can not be used as a diagnostic and prognostic factors of response to radiation therapy. VEGF pre-radiation produced an AUC of 17.5%, p 0.04 (CI 0.00-0.36), thus cannot be used as a prognostic factor for response to radiation therapy. VEGF after radiation produced an AUC of 92.5%, p 0.01 (CI 0.81-1.00), thus can be a diagnostic factor for response to radiation therapy. VEGF post-radiation with cut-off point 614.75 pg/ml had a sensitivity 80%, specificity 75%, NDP 94.12%, NDN 42.86%; RKP 3.2; RKN 0.26 and accuracy 79.16%. There is a significant correlation between the decrease of serum VEGF level post-radiation and a positive response of radiation therapy (p 0.01, CI 1.00-3.23). Conclusion: Examination of VEGF levels can be used to assess the response of radiation therapy with a sensitivity of 80% and specificity of 75%. Keywords: cervical cancer, SCC, therapeutic response, VEGF
Participation of Family Planning (KB) acceptance in the use of Long-Term Contraceptive Method (MKJP) in Indonesia is still very low. The factors that cause the low participation of KB acceptance in the use of MKJP are caused by several factors, including knowledge and attitude towards the use of MKJP. The purpose of this literature review is to explain the relationship of knowledge and attitude of KB acceptance with the use of Long Term Contraceptive Method (MKJP). The method in this literature review used systematic literature review of 20 litarature research related to topic and has been done screening. The results showed the percentage of literature related to knowledge variables as much as 95%, and unrelated 5%. The results showed literature related percentages for attitude variables as much as 90.9% and those that did not support 9.09%. According to the researchers' view and the results of data synthesis, it can be satisfied that there is a suitability of the results of literature review researchers with theoretical aspects and the results of previous research. Keywords: relationship, knowledge, attitudes, family planning, long term contraceptive method. Abstrak: Partisipasi akseptor Keluarga Berencana (KB) terhadap penggunaan Metode Kontrasepsi Jangka Panjang (MKJP) di Indonesia sampai saat ini masih sangat rendah. Faktor penyebab rendahnya partisipasi akseptor KB dalam penggunaan MKJP disebabkan beberapa faktor antara lain pengetahuan dan sikap terhadap penggunaan MKJP. Tujuan dari literature review ini adalah menjelaskan hubungan pengetahuan dan sikap akseptor KB dengan penggunaan Metode Kontrasepsi Jangka Panjang (MKJP). Metode pada literature review ini menggunakan systematic literature review terhadap 20 litarature yang berkaitan dengan topik dan telah dilakukan skrining. Hasil literature review menunjukan persentase literature yang berhubungan untuk variabel pengetahuan sebanyak 95%, dan yang tidak berhubungan 5%. Hasil penelitian menunjukan pesentase literature yang berhubungan untuk variabel sikap sebanyak 90,9% dan yang tidak mendukung 9,09%. Menurut pandangan peneliti dan hasil sintesis data, dapat disimpukan bahwa terdapat kesesuaian hasil literature review peneliti dengan aspek teoritis dan hasil penelitian terdahulu. Kata-kata kunci: hubungan, pengetahuan, sikap, program KB, MKJP.
Preeclampsia is a serious complication of pregnancy and occurs in 3-8% of all pregnancies. Preeclampsia can affect newborn, causing hypoxia, Intra Uterine Growth Retardation, preterm labor and low birth weight babies (LBW). Pregnant women are easily infected by SARS-CoV-2. Fetal complications of mothers that infected with COVID-19 include miscarried, IUGR, and preterm birth. Preeclampsia can be exacerbated or exacerbate by COVID-19 which has an impact of the condition of the newborn. The purpose of this study was to determine difference of neonatal outcomes of preeclampsia mothers with COVID-19 and without COVID-19 at Ulin Hospital Banjarmasin for the period May 2020-April 2021. This study was an analytical observational study with a retrospective approach used the Chi-square test and Fisher's exact test as an alternative. The data used was from medical records. The sample used was neonates born to preeclampsia mothers with COVID-19 and without COVID-19 at Ulin Hospital Banjarmasin for the period May 2020-April 2021, selected by purposive sampling and met the inclusion and exclusion criteria. The results showed a significant difference of the outcome of the length of stay of neonates (p= 0.002) and no significant difference of the outcomes of neonates with low birth weight (p= 0.271), preterm (p= 0.126), the 1st minute (p= 0.731) and 5th minute (p= 0.993) of APGAR score, and mortality (p= 0.240). The conclusion of this study is there was only a difference in the length of stay while the other outcomes did not. Keywords: neonatal outcome, preeclampsia, COVID-19 Abstrak: Preeklamsia merupakan komplikasi kehamilan berat dan terjadi sekitar 3-8% dari keseluruhan kehamilan. Preeklampsia dapat berpengaruh terhadap bayi yang dilahirkan, menyebabkan hipoksia, pertumbuhan janin terhambat, persalinan prematur dan bayi berat lahir rendah (BBLR). Ibu hamil mudah terinfeksi oleh SARS-CoV-2. Komplikasi janin pada ibu yang terinfeksi COVID-19 berupa keguguran, IUGR, dan kelahiran prematur. Preeklampsia dapat diperburuk atau memperburuk kehamilan dengan COVID-19 yang berdampak pada kondisi bayi yang dilahirkan. Tujuan penelitian untuk mengetahui perbedaan luaran neonatal pada ibu preeklampsia dengan COVID-19 dan tanpa COVID-19 di RSUD Ulin Banjarmasin periode Mei 2020-April 2021. Penelitian berupa observasional analitik dengan pendekatan retrospektif menggunakan uji Chi-square dan Fisher’s exact test sebagai alternatif. Data yang digunakan dari rekam medik. Sampel penelitian berupa neonatus yang lahir dari ibu preeklampsia dengan COVID-19 dan tanpa COVID-19 di RSUD Ulin Banjarmasin periode Mei 2020-April 2021, dipilih secara purposive sampling dan memenuhi kriteria inklusi dan eksklusi. Hasil penelitian terdapat perbedaan bermakna (p= 0,002) pada luaran lama rawat inap neonatus dan tidak terdapat perbedaan bermakna pada luaran neonatus dengan BBLR (p= 0,271), prematur (p= 0,126), skor APGAR neonatus menit ke-1 (p= 0,731) dan ke-5 (p= 0,993), dan meninggal (p= 0,240). Kesimpulan penelitian hanya terdapat perbedaan pada luaran lama rawat inap sedangkan luaran lainnya tidak. Kata-kata kunci: luaran neonatal, preeklampsia, COVID-19
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