The presence of lysozyme in the CSF is considered with regard to its value in the early diagnosis of primary or secondary CNS Tumours. Since the appearance of this enzyme in the CSF is secondary to the increase of protein in the fluid, the search for lysozyme in the CSF is of no practical help in the diagnosis of CNS tumours.
Neonatal subcutaneous fat necrosis (SCFN) is a transient, generally benign panniculitis that presents within several weeks of life and occurs mostly in term or post-term newborns who have a history of intrauterine or perinatal distress. It is usually a self-limited condition. Hypercalcemia is a rare but serious complication of SCFN and needs prolonged follow-up. The etiopathogenesis of both subcutaneous fat necrosis in newborn and the resultant hypercalcemia is poorly understood. We describe a classic presentation of SCFN that led to a severe hypercalcemia refractory to standard treatment. This case shows how a single dose of neridronic acid was safe and effective in managing severe hypercalcemia unresponsive to conventional therapy without hypocalcemic rebounds.
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