This study evaluated the effects of local application of autologous platelet-rich plasma (PRP) on the tooth extraction site of rats presenting the main risk factors for medication-related osteonecrosis of the jaw (MRONJ). For seven weeks, senile rats were submitted to systemic treatment with vehicle (VEH and VEH-PRP) or 100 μg/Kg of zoledronate (ZOL and ZOL-PRP) every three days. After three weeks, the first lower molar was extracted. VEH-PRP and ZOL-PRP received PRP at the tooth extraction site. Euthanasia was performed at 28 days postoperatively. Clinical, histopathological, histometric and immunohistochemical analyses were carried out in histological sections from the tooth extraction site. ZOL showed lower percentage of newly formed bone tissue (NFBT), higher percentage of non-vital bone tissue (NVBT), as well as higher immunolabeling for TNFα and IL-1β. In addition, ZOL presented lower immunolabeling for PCNA, VEGF, BMP2/4, OCN and TRAP. VEH and ZOL-PRP showed improvement in the tooth extraction site wound healing and comparable percentage of NFBT, VEGF, BMP2/4 and OCN. Local application of autologous PRP proved a viable preventive therapy, which is safe and effective to restore tissue repair capacity of the tooth extraction site and prevent the occurrence of MRONJ following tooth extraction.
Só posso agradecer e pedir para que eu continue vivendo os Seus sonhos para mim.
À minha família.À minha mãe Flávia que não mede esforços para me ver feliz, ao meu pai Régis que me guiou nos caminhos do Senhor, aos meu avós Edson e Aparecida que me criaram como filha, tios Adilson, Gi, Mariana, Vinícius e Valdir por todos os conselhos, primos Alice e Dani, ao amor da minha vida Rebeca, minha irmã/filha e em especial a você Cristine, minha mãe, amiga e protetora. Que nunca hesitou em me apoiar no que quer que seja, que não mede esforços para me ver feliz e que sonha comigo desde o princípio. Se hoje estou aqui, digo sem dúvida alguma, que é por você e para você.
Ao meu amor Pedro,Sentir que alguém faz questão de você é uma das melhores sensações desse mundo e em meio a um tempo de tantas incertezas, você me traz a certeza de nós todos os dias. Obrigada por tanto, tanto carinho, tanta cumplicidade, tanto amor e tanto cuidado.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.