Background: SARS-Cov 2 2019 (C-19) infection affects the course of various dermatological diseases. However, data on its impact on psoriasis course is limited. Objectives: To evaluate the impact of C-19 infection on psoriasis course and also investigate the frequency of post-covid complications in psoriasis patients. Methods: Psoriasis patients with at least one C-19 PCR positivity, having a control visit between March and June 2022 were included. The flare was defined as at least 25% increase in psoriasis severity within 4 weeks after C-19 PCR positivity, according to patient-reported assessment. As confounders, corticosteroid and hydroxychloroquine use and vaccination against SARS-Cov2 histories within the last 4 weeks were questioned. Also, post-covid complications were recorded. Results: 105 patients (50 female, 55 male) with a total of 113 C-19 incidents were included. Psoriasis exacerbation following C-19 was observed in 23.8% (n:25) of patients. Among 22 patients, exacerbation was similar to baseline psoriasis phenotype (1 guttate, 2 generalized pustular, 19 plaque) whereas in 3 patients with plaque psoriasis, guttate (2) and generalized pustular (1) psoriasis emerged. The risk of post-covid psoriasis flare was found to be related with discontinuation of medications or unstable psoriasis during C-19. Six patients developed post-covid complications including pericardial effusion, pulmonary thromboembolism, cerebrovascular accident, fascial paralysis and arthritis. Conclusion: This study shows a high risk of psoriasis flare following C-19, which is mostly related to unstable psoriasis during C-19 or discontinuation of medications. Since psoriasis patients have increased risk of cardiovascular complications, careful follow-up for mainly thrombotic post-covid complications is mandatory. IRB approval status: Reviewed and approved by Marmara University School of Medicine IRB (Approval number: 09.2022.339)
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