Background: Combination of thyroxine with vitamin B12 can improve the electrophysiological status of sensory function of sural nerve in newly diagnosed hypothyroid patients. Objectives: To observe the combined effects of thyroxine with vitamin B12 on electrophysiological changes in sensory function of sural nerve of newly diagnosed hypothyroid female. Materials and Methods: This prospective interventional study was carried out in the Department of Physiology, Sir Salimullah Medical College (SSMC) between July’ 2015 to June’ 2016 on 40 newly diagnosed hypothyroid female patients. Among them, 20 hypothyroid patients received only thyroxine (HT-T4) and another 20 hypothyroid patients received combined therapy of thyroxine with vitamin B12 (HT-C) for 90 consecutive days. Nerve conduction parameters of sensory functions of sural nerve were studied to observe the electrophysiological status and vitamin B12 level was also estimated to observe its level by using standard method. The statistical analysis was done by ANOVA test, paired, independent sample ‘t’ test and Chi-square (χ2) test. Results: In this study, latency was significantly decreased, amplitude and NCV were significantly increased in sensory functions of sural nerve of hypothyroid patients after 90 days supplementation of combined therapy of thyroxine with vitamin B12 in comparison to those of their pre-supplemented state and also to those of patients with only thyroxine treatment. Conclusion: The present study revealed the combination of thyroxine with vitamin B12 can reduce the symptoms of hypothyroid and accelerate the nerve conduction velocity of sensory functions of sural nerve more efficiently than the treatment with thyroxine alone. KYAMC Journal. 2022;12(04): 208-212
Background: Gradual alteration of antithyroid antibody level occurs during different trimesters of gestation. The study finds the type of alteration in Bangladeshi population. Objective: The present study was carried out to find out the alterations of antithyroid antibody levels during each trimester in normal pregnant women in Bangladesh. Materials and Methods: This cross sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka from July 2016 to June 2017. Total 90 apparently healthy pregnant women of different trimesters, age ranged from 20 to 35 years were selected as study group (Group I). Again according to gestational age, study group was subdivided into 1st trimester of gestation (Group Ia, n=30), 2nd trimester of gestation (Group Ib, n=30) and 3rd trimester of gestation (Group Ic, n=30) respectively for comparison. For assessment of antithyroid antibody status, serum TPO-Ab and Tg-Ab levels were measured by chemiluminescent microparticle immunoassay (CMIA) method in Bangabandhu Sheikh Mujib Medical University (BSMMU). The statistical analysis was done by ANOVA test and Bonferroni test. Results: In this study, mean serum TPO-Ab level was significantly (p≤0.05, p<0.001) lower in 2nd and 3rd trimester in comparison to that of 1st trimester. On the other hand, mean serum Tg-Ab level was significantly (p<0.01, p<0.001) lower in 2nd and 3rd trimester in comparison to that of 1st trimester. Again, this value was significantly (p≤0.05) lower in 3rd trimester than that of 2nd trimester. Conclusion: Antithyroid antibody titre gradually decreases with the progression of trimesters of gestation. KYAMC Journal.2021;12(02): 98-100
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