No abstract

Benzene is used commonly in industry and known as a toxic and carcinogenic agent. In this study a 100 mg.kg-1 dose was administered to Swiss Albino (Rat rattus norvegicus) rats by intraperitoneal injection. Changes in glycogen levels in the liver, muscle and blood glucose levels were investigated after 0, 2, 4, 8, 16, 32 and 64 hours. In this study increased glycogen levels in liver and muscle tissues of both control and benzene-treated rats were found to depend on nourishment. The toxic effect of benzene disappeared at 64 hours after treatment. There was no significant difference between male and female groups regarding glucose levels except at a few time intervals. In conclusion, our results indicate that glycogen levels in the liver and muscle tissues were altered by benzene while glucose in the blood remained largely unchanged

In this study we investigated the hepatotoxic effect of DNOC in rats, using biochemical serum parameters as indicators of liver disease. Experimental groups were injected intraperitoneally with 2.8 mg/kg DNOC. While an increase was determined in LDH activities for all periods, an increase was determined for urea values only up to 16 hours. In general, increased AST and ALP activities were recorded up to the 8th hour. Thereof, at later periods inhibition was observed. Inhibition was observed in female rats, while ALT activation was observed in male rats. Amylase activity inhibition was observed in both groups. Increased values were observed for cholesterol and HDL at the initial hours. No significant changes were observed in triglyceride levels. As a result, it has been observed that DNOC caused changes in serum enzyme activities and in biochemical parameters in female and male rats