Objective: The goal of cervical screening is to identify and
treat high grade cervical intraepithelial neoplasia (HSIL), in order to
reduce the incidence of the cancer. The objective of this investigation
was to analyze the sensitivity and detection rate of HSIL in urine
samples from those who tested status for HPV, as well as to assess and
contrast the histopathological findings of HPV-positive individuals in
cervical and urine specimens. Materials and Methods: This study
comprised 151 patients who had previously tested positive for HPV in
their cervical samples. The commercial real-time PCR techniques via
Roche Cobas Test were used for identification and genotyping HPV in
urine specimens. The examination of cytological and histological samples
evaluated according to Bethesda criteria and LAST PROJECT.
Results: HPV types 16, 18, and/or together OHR 100% and 80%
were present in HSIL cases in cervical and urine samples, respectively.
Urine samples had a sensitivity of 85.7% and a specificity of 32.7%
for detecting HSIL/CIN2 lesions, and a sensitivity of 83.3% and a
specificity of 36.1% for detecting HSIL/CIN3 lesions. Individuals with
HPV-positive urine had a sensitivity and specificity of 74% and 46.2%,
respectively, for identifying persistent infection. Conclusion:
HPV positivity was not detected in all urine samples due to the lack of
a standardized tool. However, urine HR-HPV screening has a high
sensitivity to determining the presence of high-grade lesions.
Furthermore, urine HR-HPV screening may be used as a predictive tool for
the persistence of HPV infection.
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