Document-level relation extraction is a complex human process that requires logical inference to extract relationships between named entities in text. Existing approaches use graphbased neural models with words as nodes and edges as relations between them, to encode relations across sentences. These models are node-based, i.e., they form pair representations based solely on the two target node representations. However, entity relations can be better expressed through unique edge representations formed as paths between nodes. We thus propose an edge-oriented graph neural model for document-level relation extraction.

We present a novel graph-based neural network model for relation extraction. Our model treats multiple pairs in a sentence simultaneously and considers interactions among them. All the entities in a sentence are placed as nodes in a fully-connected graph structure. The edges are represented with position-aware contexts around the entity pairs. In order to consider different relation paths between two entities, we construct up to l-length walks between each pair. The resulting walks are merged and iteratively used to update the edge representations into longer walks representations. We show that the model achieves performance comparable to the state-ofthe-art systems on the ACE 2005 dataset without using any external tools.

Inter-sentence relation extraction deals with a number of complex semantic relationships in documents, which require local, non-local, syntactic and semantic dependencies. Existing methods do not fully exploit such dependencies. We present a novel inter-sentence relation extraction model that builds a labelled edge graph convolutional neural network model on a document-level graph. The graph is constructed using various inter-and intra-sentence dependencies to capture local and non-local dependency information. In order to predict the relation of an entity pair, we utilise multi-instance learning with bi-affine pairwise scoring. Experimental results show that our model achieves comparable performance to the state-of-the-art neural models on two biochemistry datasets. Our analysis shows that all the types in the graph are effective for inter-sentence relation extraction.

Objective Identification of drugs, associated medication entities, and interactions among them are crucial to prevent unwanted effects of drug therapy, known as adverse drug events. This article describes our participation to the n2c2 shared-task in extracting relations between medication-related entities in electronic health records. Materials and Methods We proposed an ensemble approach for relation extraction and classification between drugs and medication-related entities. We incorporated state-of-the-art named-entity recognition (NER) models based on bidirectional long short-term memory (BiLSTM) networks and conditional random fields (CRF) for end-to-end extraction. We additionally developed separate models for intra- and inter-sentence relation extraction and combined them using an ensemble method. The intra-sentence models rely on bidirectional long short-term memory networks and attention mechanisms and are able to capture dependencies between multiple related pairs in the same sentence. For the inter-sentence relations, we adopted a neural architecture that utilizes the Transformer network to improve performance in longer sequences. Results Our team ranked third with a micro-averaged F1 score of 94.72% and 87.65% for relation and end-to-end relation extraction, respectively (Tracks 2 and 3). Our ensemble effectively takes advantages from our proposed models. Analysis of the reported results indicated that our proposed approach is more generalizable than the top-performing system, which employs additional training data- and corpus-driven processing techniques. Conclusions We proposed a relation extraction system to identify relations between drugs and medication-related entities. The proposed approach is independent of external syntactic tools. Analysis showed that by using latent Drug-Drug interactions we were able to significantly improve the performance of non–Drug-Drug pairs in EHRs.