A nitrogen-centered radical-mediated strategy for preparing 1,2-trans-2-amino-2-deoxyglycosides in one step was established. The cascade amidoglycosylation was initiated by a benzenesulfonimide radical generated from NFSI under the catalytic reduction of TEMPO. The benzenesulfonimide radical was electrophilically added to the glycals, and then the resulting glycosidic radical was converted to oxocarbenium upon oxidation by TEMPO + , which enabled the following anomeric specific glycosylation.
An efficient and practical strategy of nitrogen-centered radical mediated α-sulfonimidation of carbonyl compounds was established. The ketone α-sulfonimidation was initiated by a benzenesulfonimide radical generated from NFSI under the catalytic...
A nitrogen-centered radical-mediated strategy to prepare 1,2-trans 2-amino-2-deoxyglycosides in one step was established. The cascade amidoglycosylation was initiated by a benzenesulfonimide radical generated from NFSI under the catalytic reduction of TEMPO. The benzenesulfonimide radical electrophilic added to the glycals, then the resulted glycosidic radical was converted to oxocarbenium upon oxidation by TEMPO+, and enabled the following anomeric specific glycosylation.
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