Convolutional neural network (CNN)-based deep learning techniques have enjoyed many successful applications in the field of medical imaging. However, the complicated between-manifold projection from the projection domain to the spatial domain hinders the direct application of CNN techniques in computed tomography (CT) reconstruction. In this work, we proposed a novel CT reconstruction framework based on a CNN, i.e., an intelligent back-projection network (iBP-Net). The proposed iBP-Net method fused a pre-CNN, a back-projection layer, and a post-CNN into an end-to-end network. The pre-CNN adopted CNN techniques to model a filtering operation in the projection domain. In the back-projection layer, a back-projection operation was employed to perform between-manifold projection. Based on CNN techniques, the post-CNN worked together with the pre-CNN to recover reconstructed images from the outputs of the back-projection layer in the spatial domain while maintaining high visual sensitivity. The experimental results demonstrate the feasibility of the proposed iBP-Net framework for CT reconstruction.
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