A visible-light promoted radical cascade reaction of N-propargylanilines with sodium sulfinates as sulfonyl radical precursors was developed under metal-free conditions.
A novel metal-and catalyst-free dearomative reaction of 2-oxypyridines to construct gem-difluoromethylenated Nsubstituted 2-pyridones has been developed. The reaction involves an attractive acyl rearrangement from O to CF 2 of difluorocarbene-derived pyridinium ylides, which provides a new strategy for the direct introduction of the gem-difluoromethylene group with high efficiency and selectivity as well as broad substrate scope. Gram-scale synthesis and synthetic transformations have also been demonstrated.
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