Background: The liver iron concentration (LICF) provided by FerriScan is already certified. But there are some restrictive factors. Therefore, we explored the relationship curves of LICF and MRI liver T2 *, and constructed the equations for both. Methods: Liver MRI T2* values of 273 thalassemia patients were measured by CMRtools/Thalassemia Tools (CMRtools) and divided into test and verification groups. The T2* values of the test group and LICF were used to build the equation, through which the T2* values of the validation group were converted to the liver iron concentration(LICe). The relationship between LICe and LICF was explored. According to the clinical liver iron concentration grading, LICF and LICe were grouped to explore the relationship between the them in the validation group. Results: The equation built by the test group was LICF=37.393T2*^(-1.22)(R2=0.971,P<0.05). There was no statistical difference between LICe and LICF in the validation group(P>0.05); There was significant consistency(W=0.991, P<0.05)and significant correlation(rs=0.983,P<0.05) between them .There was no statistical difference in the clinical grading between LICe and LICF in the validation group (P>0.05). There was significant consistency between the clinical grading results(K=0.943,P<0.05. Conclusion: Through the equation LICF=37.393T2*^(-1.22), after measuring the liver T2* value, the liver iron concentration (LIC) equivalent to LICF can be accurately calculated.
In the sentence beginning 'Among the 195 patients included, there were 130 males and 91 females, aged from 5 to 49 years old, with an average of (22.2 ± 11.3) years old.' In this article, the value '130' should be revised as '104'.
Background Due to the small sample size of many studies, it remained unclear what standardized reference range the T2* cutoff at 3 T would be used to assess the severity of cardiac iron load. In addition, the number of patients with moderate to severe cardiac iron load was small in some studies, especially the sample of patients with severe cardiac iron load. Purpose To explore the feasibility, reproducibility, and reliability of using T2* values in quantifying cardiac iron load in patients with thalassemia at 3 T. Material and Methods A total of 122 patients with thalassemia underwent cardiac T2* imaging at both 1.5 T and 3 T. Cardiac R2* (1000/T2*) values of the 100 patients at 3 T were fitted against the values at 1.5 T using linear regression and the prediction equation was derived. The remaining 22 cases were used to test the prediction accuracy of the equation. Results The combined R2* values exhibited a strong linear relationship between 1.5 T and 3 T ( r = 0.830, P<0.001). At the center, it had a slope of 1.348 and an intercept of 37.279. According to the equation, the truncated T2* values of cardiac iron overload and cardiac heavy iron overload at 3 T were <10 ms and <6 ms, respectively. The two truncated T2* values were used to diagnose different levels of cardiac iron overloaded of 22 patients at 3 T; the accuracy rates were 95.5% and 100.0%, respectively. Conclusion T2* quantification of cardiac iron load at 3 T MRI resulted to be feasible, reproducible, and reliable.
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