Gestational diabetes mellitus (GDM) refers to the first sign or onset of diabetes mellitus during pregnancy rather than progestation. In recent decades, more and more research has focused on the etiology and pathogenesis of GDM in order to further understand GDM progress and recovery. Using an advanced metabolomics platform based on ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS), we explored the changes in serum metabolites between women with GDM and healthy controls during and after pregnancy. Some significant differences were discovered using multivariate analysis including partial least-squares discriminant analysis (PLS-DA) and orthogonal PLS-DA (OPLS-DA). The dysregulated metabolites were further compared and verified in several databases to understand how these compounds might function as potential biomarkers. Analyses of the metabolic pathways associated with these potential biomarkers were subsequently explored. A total of 35 metabolites were identified, contributing to GDM progress to some extent. The identified biomarkers were involved in some important metabolic pathways including glycine, serine, and threonine metabolism; steroid hormone biosynthesis; tyrosine metabolism; glycerophospholipid metabolism; and fatty acid metabolism. The above mentioned metabolic pathways mainly participate in three major metabolic cycles in humans, including lipid metabolism, carbohydrate metabolism, and amino acid metabolism. In this pilot study, the valuable comprehensive analysis gave us further insight into the etiology and pathophysiology of GDM, which might benefit the feasibility of a rapid, accurate diagnosis and reasonable treatment as soon as possible but also prevent GDM and its related short- and long-term complications.
Objective: To investigate the relationship between reactive hyperemia index(RHI) in patients with coronary heart disease (CHD) with the cardiac function and prognosis, intervention so as to provide guidance for coronary heart disease severity and prognosis assessment. Methods: 500 cases of volunteers had coronary artery angiography by Judkins method in our hospital. coronary angiography showing one or more quarantine branch of coronary artery stenosis lower than 50% or more were taken as the standard for coronary heart disease diagnosis, and the volunteers were divided into CHD group (n=81) and health group (n=419). RHI and left ventricular ejection fraction (LVEF) of two groups were detected. The CHD group were followed up for 1 year and survival prognosis and cardiovascular events prognosis of the patients were statistically analyzed and the relationship between RHI and LVEF, cardiovascular events rate and mortality were analyzed. Results: Compared with health group, RHI and LVEF of CHD group were lower ( P <0. 05). RHI of patient in CHD group with LVEF ≥ 50% were higher than that of patient with LVEF < 50% ( P <0. 05). Pearson correlation analysis results showed that RHI and LVEF of CHD patients were positively correlated (r=0.827, P <0. 05). Coronary heart disease group were followed up for 1 year and the cardiovascular events rates and mortality rates were 28.40% and 9.88% respectively, and RHI and LVEF of patient with cardiovascular events were lower than that of patients without coronary heart disease, and RHI and LVEF of death patients were also lower than that of survived patients ( P <0. 05). Spearman unconditionally correlation analysis results showed that the RHI and cardiovascular events and mortality in patients with CHD are negatively correlated (r=-0.794, -0.762, P <0. 05). Conclusion: RHI in CHD patients is lower and closely related to the cardiac function and prognosis, this may be related to RHI reflecting endothelial function and endothelial function damage of CHD associating with disease development, therefore, RHI may be reference indicators of disease severity and prognosis assessment of CHD.
Objective: Through propaganda and education on lifestyle change, we study the effects on metabolism and vascular lesions in healthy people. Methods: the healthy subjects that conform to the requirements, through propaganda and education on vascular health, through moderate exercise, proper control of starchy foods, low salt, low fat diet, reduce smoking and other lifestyle changes, compare changes in weight, renal function, fasting blood glucose, blood lipids and ankle brachial index (ABI), cardio ankle vascular index(CAVI) before and after lifestyle changes. Results: After lifestyle changed, the subjects’ body mass index [(23.13±3.18)kg/m 2 vs (22.67±3.36)kg/m 2 ], ABI[1.11±0.08 vs 1.09±0.09], CAVI[(7.14±1.13 ) vs (7. 01±1.18) ], serum creatinine[(84.31±22.41)umol/L vs (79.92±23.64)umol/L], blood uric acid[(337.79±102.17 )umol/L vs (328.12±88.33)umol/L], low density lipoprotein cholesterol[(2.49±0.65) mmol/L vs (2.37±0.69) mmol/L],all have good changes. Conclusion: Healthy lifestyle is good for metabolism and early vascular lesions, can improve metabolic disorder and slow the occurrence of arteriosclerosis.
BackgroundCOVID-19 (coronavirus disease 2019) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seriously endangers people's lives. The variation in SARS-CoV-2 makes the research and development of vaccines and specific drugs particularly important. However, the prevention and diagnosis of COVID-19 cannot be underestimated in the control of the epidemic.Case PresentationWe introduced a 65-year-old female patient who was diagnosed with COVID-19. The SARS-CoV-2 nucleic acid test result of this patient was positive again during treatment. It took 85 days from the first symptom to the final cure. According to the known reports, she is currently the patient with the longest virus shedding in Sichuan Province, China. Due to the patient's special condition, she was treated in four hospitals before and after, and she was diagnosed with type 2 diabetes mellitus (T2DM) and right lung metastatic adenocarcinoma. We fully introduced the patient's epidemiological history, diagnosis, testing, and treatment process. The patient was finally discharged from the hospital under the treatment of antiviral, hypoglycaemic, anti-anxiety, and a combination of Chinese and Western medicine.ConclusionsThe epidemic is still rampant, and we should not relax our efforts in the prevention and control of viruses. For the elderly, especially those who are suffering from complications or vulnerable to diseases, it is recommended to extend the observation time. Additionally, medical workers should pay attention to the mental state of patients.
In 2021, National Health Commission of the People's Republic of Chinese issued a document that no longer recommended the routine skin test for cephalosporin (RSTC). However, there is still resistance to the cancellation of RSTC in a primary hospital. The study aimed to explore the potential factors for hindering the abolition of the RSTC in a county-level hospital based on the PRECEDE model. Methods: The cross-sectional study was conducted on healthcare workers in the Pidu District People's Hospital, Chengdu, by online questionnaire from September 10 to September 25 in the 2021.The PRECEDE model was used to divide the potential factors of healthcare professionals in hindering the abolition of the RSTC into predisposing factors, enabling factors and reinforcing factors. Data were analyzed by ANOVA, Chi-square test, multiple linear and multiple logistic regression analysis. Results: We collected 605 respondents' valid questionnaires. 254 healthcare professionals were against cancellation of the RSTC, accounting for 41.98%. Multiple linear regression analysis showed that working for 6~10 years (β = 1.953, P = 0.024), medium (β = 1.995, P = 0.030) or senior (β = 4.003, P = 0.007) professional qualification, pharmacists (β = 3.830, P = 0.013) and working in surgical department (β= 4.462, P < 0.001) were significantly associated with higher score of predisposing factors, enabling factors, and reinforcing factors on abolition of RSTC. Furthermore, multiple logistic regression analysis showed that pharmacists (OR=3.113, 95% CI: 1.341-7.223, P=0.030), medium professional qualification (OR=1.272, 95% CI: 0.702-2.302, P=0.008), scores of predisposing factors (OR=1.335, 95% CI: 1.033-1.726, P=0.009), and scores of enabling factors (OR=1.208, 95% CI: 1.109-1.315, P<0.001) were independently associated with the positive anticipated behavior on the abolition of RSTC. While nurses (OR=0.516, 95% CI: 0.284-0.938, P<0.001) were independently associated with anticipated negative behavior. Conclusion: Pharmacists, medium professional qualification, and healthcare professionals with higher scores of predisposing and enabling factors were more likely to have a positive anticipated behavior on the abolition of RSTC, while nurses did not.
Objective: To investigate the correlations between NT-proBNP and Cardiac contractility reserve index(CCRI) and Cardiac reserve index(CRI) and find more theoretical and clinical evidence that CRI, CCRI can reflect the degree of heart failure,promote the use of them in the Primary hospitals and community health service centers. Methods: According to the inclusion and exclusion criteria,155 cases were included in the study, 60 volunteers without cardiovascular disease were selected as the control group, all of them were classed by NYHA functional classification, phonocardiogra were recorded by phonocardiogram exercise test (PCGET) before and after 6 minutes walk test, measured S1 amplitude and heart rate, calculated CCRI, CRI, detected NT-proBNP, and analysed the CCRI, CRI, and NT proBNP correlations. Results: Compared with the healthy group, the NT-proBNP, CCRI, CRI, 6 minutes walking distance were significantly different in different NYHA FC, Moreover, with the increase of NYHA FC level, CRI, CCRI gradually decreased, 6 minutes walk distance gradually shortened, NT-proBNP gradually increased, the differences were statistically significant. Conclusion: The CCRI, CRI and NT- proBNP have good correlations, so they can reflect the classification of cardiac function, they are facilitate, economic, no invasive, rapid, they are worth using widely in primary hospitals and community health service centers.
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