Objective. To study the therapeutic effects of metformin in combination with medroxyprogesterone in the early endometrial cancer patients with fertility requirements. A total of 120 patients with early endometrial cancer admitted to and treated in our hospital were enrolled and evenly assigned into two groups according to different therapeutic regimens, namely, metformin group (metformin combined with medroxyprogesterone acetate) and control group (medroxyprogesterone acetate alone). The objective response rate (ORR) and disease control rate (DCR) were 71.7% (43/60) and 90.0% (54/60) in the metformin group and 53.3% (32/60) and 78.3% (47/60) in the control group, respectively. Adverse reactions such as gastrointestinal reaction, headache, and insomnia were mainly observed in patients. The body mass index (BMI) declined from (34.43 ± 4.34) kg/m2 to (24.77 ± 2.39) kg/m2 in the metformin group and from (33.37 ± 4.49) kg/m2 to (31.28 ± 3.55) kg/m2 in the control group after treatment. After treatment, serum levels of vascular endothelial growth factor (VEGF), angiotensin-2 (Ang-2), carbohydrate antigen 125 (CA125), and CA19-9 in the metformin group were significantly lower than those in the control group (P = 0.005, P < 0.001, P = 0.002, and P < 0.001). During follow-up, the pregnancy rate was 81.7% (49/60) in the metformin group and 61.7% (37/60) in the control group, and the former was prominently higher than the latter (P = 0.025). Metformin in combination with progesterone is effective in treating early endometrial cancer patients with fertility requirements, which significantly reduced the BMI of patients and increased the pregnancy rate after treatment.
Objective: To observe the clinical effect of different frequencies of transcutaneous electrical acupoint stimulation in treating postpartum pelvic girdle pain and promoting postpartum rehabilitation. Methods: From January to September 2022, 300 patients with pelvic girdle pain after spontaneous delivery in a hospital in Shaanxi Province were selected and randomly divided into three groups, low frequency, high frequency, and alternating frequency, with 100 cases in each group. In addition to routine postpartum care and psychological counseling, the three groups received transcutaneous electrical acupoint stimulation at low-frequency (2 Hz,) high-frequency (100 Hz), and alternating frequency (2/100 Hz), respectively. The differences in initial pain, pain scores before and after treatment, satisfaction with analgesic effect, and postpartum rehabilitation effect were evaluated among the three groups of patients. Results: There was a significant correlation between maternal age and postpartum pelvic girdle pain (P < 0.001), but no correlation was observed between newborn birth weight and postpartum pelvic girdle pain (P > 0.05). After 1d/2d of treatment, the pain scores and rehabilitation effect of patients in the alternating-frequency group and low-frequency group were significantly better than those in the high-frequency group, and the postpartum curative effect of patients in the alternating-frequency group was the best, followed by the low-frequency group, and the high-frequency group; the differences were statistically significant (P < 0.001). Among the three groups, the alternating-frequency group had the highest satisfaction with the analgesic effect and the highest rate of selecting the same analgesic regimen the next time; the differences were statistically significant (P < 0.001). Conclusion: Transcutaneous electrical acupoint stimulation at different frequencies is safe and effective in treating postpartum pelvic girdle pain and beneficial to postpartum rehabilitation. Sparse-dense wave stimulation is effective in treating postpartum pelvic girdle pain. It has the best effect in promoting postpartum rehabilitation and the highest patient satisfaction. Therefore, its application in clinical practice is highly recommended.
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