Mutation in the 1A domain of keratin 17 underlies the affected members' phenotype, PC-2 with early onset sebaceous cysts and late-onset thickened fingernails and toenails. The onset of the cysts is very early in some people within this family and the age at onset of thickened fingernails and toenails is variable within the family, implying the existence of modifying factors.
Loffler et al. 3 found a significant association between perceived sensitive skin and nickel allergy. However, these authors found no significant differences between individuals who perceived they have sensitive skin and those who didn't in skin hydration, skin blood flow and transepidermal water loss tests. Therefore, it was proposed that self-perceived 'sensitive skin' is a fashionable, noncausative complaint. In this study, 2 a significant association has been demonstrated between self-perceived sensitive skin and self-reported skin allergies (an immunological link) and family history (a familial link).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.