Organic transistor with DNA‐damage evaluation ability can open up novel opportunities for bioelectronic devices. Even though trace amounts of drugs can cause cumulative gene damage in vivo, the extremely low occurrence proportion makes them hardly transduced into detectable electric signals. Here, an ultrasensitive DNA‐damage sensor based on an oligonucleotide‐distortion‐responsive organic transistor (DROT) is reported by creating controllable conformation change of double‐stranded DNA on the surface of organic semiconductors. In combination with interfacial charge redistribution and efficient signal amplification, the DROT provides an ultrasensitive single‐site DNA‐damage response with 20.5 s even upon 1 × 10−12 m cisplatin. The high generalizability of this DROT to three generations of classical platinum drugs and gene‐relevant DNA damage is demonstrated. A biochip is further designed for intelligent damage analysis in complex environments, which holds the potential for high‐throughput biotoxicity evaluation and drug screening in the future.
Lithium metal batteries hold promise for energy storage applications but suffer from uncontrolled lithium dendrites. In this study, a new composite membrane based on modified natural polymer and ZIF‐67 is designed and prepared by the in situ composite method for the first time. Among them, a modified natural polymer composed of lithium alginate (LA) and polyacrylamide (PAM) can be obtained by electrospinning. Importantly, the polar functional groups of natural polymers can interact by hydrogen bonding and MOFs can construct lithium‐ion transport channels. Consequently, compared with LA‐PAM electrolyte without MOF, the electrochemical stability window of ZIF‐67‐LA‐PAM electrolyte becomes wider from 4.5 to 5.2 V, and the lithium‐ion transference number (
t
Li+
) enhances from 0.326 to 0.627 at 30°C. It is worth noting that the symmetric cells with ZIF‐67‐LA‐PAM have superior stable cycling performance at 40 and 100 mA cm
−2
, and a high rate at 10C and 20C for LFP cells. Besides, the cell with NCM811 high‐voltage cathode can run stably for 400 cycles with an initial discharge capacity of 136.1 mAh g
−1
at 0.5C. This work provides an effective method for designing and preparing MOF‐natural polymer composite electrolytes and exhibits an excellent application prospect in high‐energy‐density lithium metal batteries.
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