Computer-assisted diagnosis is key for scaling up cervical cancer screening. However, current recognition algorithms perform poorly on whole slide image (WSI) analysis, fail to generalize for diverse staining and imaging, and show sub-optimal clinical-level verification. Here, we develop a progressive lesion cell recognition method combining low- and high-resolution WSIs to recommend lesion cells and a recurrent neural network-based WSI classification model to evaluate the lesion degree of WSIs. We train and validate our WSI analysis system on 3,545 patient-wise WSIs with 79,911 annotations from multiple hospitals and several imaging instruments. On multi-center independent test sets of 1,170 patient-wise WSIs, we achieve 93.5% Specificity and 95.1% Sensitivity for classifying slides, comparing favourably to the average performance of three independent cytopathologists, and obtain 88.5% true positive rate for highlighting the top 10 lesion cells on 447 positive slides. After deployment, our system recognizes a one giga-pixel WSI in about 1.5 min.

Quadrature compressive sampling (QuadCS) is a recentlyintroduced sub-Nyquist sampling scheme for effective acquisition of inphase and quadrature (I/Q) components of sparse radio frequency signals. In applications to pulse-Doppler radars, the QuadCS outputs can be arranged into a two-dimensional data format, in terms of slow time and virtual fast time, similar to that by Nyquist sampling. This paper develops a compressive sampling pulse-Doppler (CoSaPD) processing scheme which performs Doppler estimation/detection and range estimation from the sub-Nyquist data without recovering the Nyquist samples. The Doppler estimation is realized through a spectrum analyzer as in classical processing, whereas the detection is performed using the Doppler bin data. The range estimation is performed using sparse recovery algorithms only for the detected targets to reduce the computational load. A low detection threshold is used to improve the detection probability and the introduced false targets are then removed in the range estimation stage by exploiting the inherent target detection capability of the recovery algorithms. Simulation results verify the effectiveness of the proposed CoSaPD scheme, which requires only one-eighth of the Nyquist rate to achieve similar performance to the classical processing with Nyquist samples, provided that the input signal-to-noise ratio (SNR) is above −25 dB.

We investigate the one-bit MIMO (1b-MIMO) radar that performs one-bit sampling with a timevarying threshold in the temporal domain and employs compressive sensing in the spatial and Doppler domains. The goals are to significantly reduce the hardware cost, energy consumption, and amount of stored data. The joint angle and Doppler frequency estimations from noisy one-bit data are studied.By showing that the effect of noise on one-bit sampling is equivalent to that of sparse impulsive perturbations, we formulate the one-bit ℓ 1 -regularized atomic-norm minimization (1b-ANM-L1) problem to achieve gridless parameter estimation with high accuracy. We also develop an iterative method for solving the 1b-ANM-L1 problem via the alternating direction method of multipliers. The Cramér-Rao bound (CRB) of the 1b-MIMO radar is analyzed, and the analytical performance of one-bit sampling with two different threshold strategies is discussed. Numerical experiments are presented to show that the 1b-MIMO radar can achieve high-resolution parameter estimation with a largely reduced amount of data.

Sequential estimation of the delay and Doppler parameters for sub-Nyquist radars by analog-to-information conversion (AIC) systems has received wide attention recently. However, the estimation methods reported are AIC-dependent and have poor performance for off-grid targets. This paper develops a general estimation scheme in the sense that it is applicable to all AICs regardless whether the targets are on or off the grids. The proposed scheme estimates the delay and Doppler parameters sequentially, in which the delay estimation is formulated into a beamspace direction-ofarrival problem and the Doppler estimation is translated into a line spectrum estimation problem. Then the well-known spatial and temporal spectrum estimation techniques are used to provide efficient and high-resolution estimates of the delay and Doppler parameters. In addition, sufficient conditions on the AIC to guarantee the successful estimation of off-grid targets are provided, while the existing conditions are mostly related to the on-grid targets. Theoretical analyses and numerical experiments show the effectiveness and the correctness of the proposed scheme.