A very simple and high efficient synthetic protocol for tetra- and penta-substituted benzene derivatives has been provided by tetramethylguanidine (TMD) promoted reaction of 4-(N,N-dimethylamino)-1-phenacyl-pyridinium bromide with chalcone o-enolates in DMF...
Triethylamine promoted cycloaddition reaction of phenacylmalononitriles and o-hydroxychalcones in ethanol at room temperature resulted in multifunctionalized cyclopent-3-ene-1-carboxamides in good yields and with high diastereoselectivity. More importantly, the similar reaction of...
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