Background: To compare the depiction conspicuity of three-dimensional (3D) magnetic resonance cholangiopancreatography (MRCP) based on gradient-and spin-echo (GRASE) and two-dimensional (2D) thick-slab MRCP using fast spin-echo (FSE) in different segments of hepatic and pancreatic ducts at 3T. Methods: Both 3D GRASE and 2D thick-slab FSE MRCP, with parameters adjusted under the constraints of specific absorption rate and scan time within single breath-hold, were performed for 95 subjects (M/F =49:46; age range, 25-75) at 3T. Conspicuity of eight ductal segments was graded by two experienced raters using a 4-point score. Situations where one technique is superior or inferior to the other were recorded.Results: 3D GRASE MRCP outperformed 2D thick-slab FSE MRCP in the common bile duct and common hepatic ducts (both with P<0.001), but compared inferiorly in the right hepatic ducts (P<0.001), right posterior hepatic ducts (P<0.005) and pancreatic duct distal (P<0.05). Performing both 3D and 2D MRCP would reduce the number of non-diagnostic readings in the left hepatic duct to 10 remaining (5.3%), compared with 31 (16.3%) or 21 (11.1%) out of 190 readings if using 3D GRASE or 2D thick-slab FSE alone, respectively.Conclusions: Although 3D GRASE MRCP is preferential to visualize the common bile duct and common hepatic duct within one single breath-hold, the complementary role of 2D thick-slab FSE MRCP in smaller hepatic and pancreatic ducts makes it a useful adjunct if performed additionally.
The intravoxel incoherent motion (IVIM) model may enhance the clinical value of multiparametric magnetic resonance imaging (mpMRI) in the detection of prostate cancer (PCa). However, while past IVIM modeling studies have shown promise, they have also reported inconsistent results and limitations, underscoring the need to further enhance the accuracy of IVIM modeling for PCa detection. Therefore, this study utilized the control point registration toolbox function in MATLAB to fuse T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) MRI images with whole-mount pathology specimen images in order to eliminate potential bias in IVIM calculations. Sixteen PCa patients underwent prostate MRI scans before undergoing radical prostatectomies. The image fusion method was then applied in calculating the patients’ IVIM parameters. Furthermore, MRI scans were also performed on 22 healthy young volunteers in order to evaluate the changes in IVIM parameters with aging. Among the full study cohort, the f parameter was significantly increased with age, while the D* parameter was significantly decreased. Among the PCa patients, the D and ADC parameters could differentiate PCa tissue from contralateral normal tissue, while the f and D* parameters could not. The presented image fusion method also provided improved precision when comparing regions of interest side by side. However, further studies with more standardized methods are needed to further clarify the benefits of the presented approach and the different IVIM parameters in PCa characterization.
Owing to its capacity to eliminate a long-standing methodological limitation, fiber photometry can assist research gaining novel insight into neural systems. Fiber photometry can reveal artifact-free neural activity under deep brain stimulation (DBS). Although evoking neural potential with DBS is an effective method for mediating neural activity and neural function, the relationship between DBS-evoked neural Ca2+ change and DBS-evoked neural electrophysiology remains unknown. Therefore, in this study, a self-assembled optrode was demonstrated as a DBS stimulator and an optical biosensor capable of concurrently recording Ca2+ fluorescence and electrophysiological signals. Before the in vivo experiment, the volume of tissue activated (VTA) was estimated, and the simulated Ca2+ signals were presented using Monte Carlo (MC) simulation to approach the realistic in vivo environment. When VTA and the simulated Ca2+ signals were combined, the distribution of simulated Ca2+ fluorescence signals matched the VTA region. In addition, the in vivo experiment revealed a correlation between the local field potential (LFP) and the Ca2+ fluorescence signal in the evoked region, revealing the relationship between electrophysiology and the performance of neural Ca2+ concentration behavior. Concurrent with the VTA volume, simulated Ca2+ intensity, and the in vivo experiment, these data suggested that the behavior of neural electrophysiology was consistent with the phenomenon of Ca2+ influx to neurons.
Delayed graft function (DGF) is a form of acute renal failure that results in post-transplantation oliguria, with various frequencies from 2% to 50%. Heretofore, there was a lack of imaging biomarkers to interpolate the DGF. The tri-exponential intravoxel incoherent motion (IVIM) model, providing three distinct signal fractions of a pure diffusion, an intermediate and an ultrafast component, is more preferable for the diffusion signal in the allograft kidneys than the mono- and bi-exponential models. Our experiment illustrates that tri-exponential IVIM model could provide a good indicator for distinguishing the early graft function, the delayed graft function without and with complications.
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