Zellner's g-prior remains a popular conventional prior for use in Bayesian variable selection, despite several undesirable consistency issues. In this paper, we study mixtures of g-priors as an alternative to default g-priors that resolve many of the problems with the original formulation, while maintaining the computational tractability that has made the g-prior so popular. We present theoretical properties of the mixture g-priors and provide real and simulated examples to compare the mixture formulation with fixed g-priors, Empirical Bayes approaches and other default procedures.

This paper proposes a deep learning approach for accelerating magnetic resonance imaging (MRI) using a large number of existing high quality MR images as the training datasets. An off-line convolutional neural network is designed and trained to identify the mapping relationship between the MR images obtained from zero-filled and fully-sampled k-space data. The network is not only capable of restoring fine structures and details but is also compatible with online constrained reconstruction methods. Experimental results on real MR data have shown encouraging performance of the proposed method for efficient and effective imaging.

Linked or networked data are ubiquitous in many applications. Examples include web data or hypertext documents connected via hyperlinks, social networks or user profiles connected via friend links, co-authorship and citation information, blog data, movie reviews and so on. In these datasets (called "information networks"), closely related objects that share the same properties or interests form a community. For example, a community in blogsphere could be users mostly interested in cell phone reviews and news. Outlier detection in information networks can reveal important anomalous and interesting behaviors that are not obvious if community information is ignored. An example could be a low-income person being friends with many rich people even though his income is not anomalously low when considered over the entire population. This paper first introduces the concept of community outliers (interesting points or rising stars for a more positive sense), and then shows that wellknown baseline approaches without considering links or community information cannot find these community outliers. We propose an efficient solution by modeling networked data as a mixture model composed of multiple normal communities and a set of randomly generated outliers. The probabilistic model characterizes both data and links simultaneously by defining their joint distribution based on hidden Markov random fields (HMRF). Maximizing the data likelihood and the posterior of the model gives the solution to the outlier inference problem. We apply the model on both

Let X|µ ∼ Np(µ, vxI) and Y |µ ∼ Np(µ, vyI) be independent pdimensional multivariate normal vectors with common unknown mean µ. Based on only observing X = x, we consider the problem of obtaining a predictive densityp(y|x) for Y that is close to p(y|µ) as measured by expected Kullback-Leibler loss. A natural procedure for this problem is the (formal) Bayes predictive densitypU(y|x) under the uniform prior πU(µ) ≡ 1, which is best invariant and minimax. We show that any Bayes predictive density will be minimax if it is obtained by a prior yielding a marginal that is superharmonic or whose square root is superharmonic. This yields wide classes of minimax procedures that dominatepU(y|x), including Bayes predictive densities under superharmonic priors. Fundamental similarities and differences with the parallel theory of estimating a multivariate normal mean under quadratic loss are described.

A novel noninvasive second-harmonic-generation tomographic method of mapping the structure of animal tissues by use of 100-fs laser pulses at 625nm is described. Subsurface structures were measured with this approach, which is potentially a symmetry-sensitive tool for optical histological reconstruction.

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© 2 0 0 3 m a s s a c h u s e t t s i n s t i t u t e o f t e c h n o l o g y, c a m b r i d g e , m a 0 2 1 3 9 u s a -w w w. a i . m i t . e d u m a s s a c h u s e t t s i n s t i t u t e o f t e c h n o l o g y -a r t i f i c i a l i n t e l l i g e n c e l a b o r a t o r y @ MIT AbstractWe introduce and explore an approach to estimating statistical significance of classification accuracy, which is particularly useful in scientific applications of machine learning where high dimensionality of the data and the small number of training examples render most standard convergence bounds too loose to yield a meaningful guarantee of the generalization ability of the classifier. Instead, we estimate statistical significance of the observed classification accuracy, or the likelihood of observing such accuracy by chance due to spurious correlations of the high-dimensional data patterns with the class labels in the given training set. We adopt permutation testing, a non-parametric technique previously developed in classical statistics for hypothesis testing in the generative setting (i.e., comparing two probability distributions). We demonstrate the method on real examples from neuroimaging studies and DNA microarray analysis and suggest a theoretical analysis of the procedure that relates the asymptotic behavior of the test to the existing convergence bounds.

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