In this paper we consider a collection of single-antenna ground nodes communicating with a multiantenna unmanned aerial vehicle (UAV) over a multiple-access ground-to-air wireless communications link. The UAV uses beamforming to mitigate the inter-user interference and achieve spatial division multiple access (SDMA). First, we consider a simple scenario with two static ground nodes and analytically investigate the effect of the UAV heading on the system sum rate. We then study a more general setting with multiple mobile ground-based terminals, and develop an algorithm for dynamically adjusting the UAV heading in order to maximize a lower bound on the ergodic sum rate of the uplink channel, using a Kalman filter to track the positions of the mobile ground nodes. Fairness among the users can be guaranteed through weighting the bound for each user's ergodic rate with a factor inversely proportional to their average data rate. For the common scenario where a high K-factor channel exists between the ground nodes and UAV, we use an asymptotic analysis to find simplified versions of the algorithm for low and high SNR. We present simulation results that demonstrate the benefits of adapting the UAV heading in order to optimize the uplink communications performance. The simulation results also show that the simplified algorithms perform near-optimal performance.

In the important human pathogen Staphylococcus aureus the cytoplasmic ClpP protease is essential for mounting cellular stress responses and for virulence. To directly identify substrates of the ClpP protease, we expressed in vivo a proteolytic inactive form of ClpP (ClpP(trap)) that will retain but not degrade substrates translocated into its proteolytic chamber. Substrates captured inside the proteolytic barrel were co-purified along with the His-tagged ClpP complex and identified by mass spectrometry. In total, approximately 70 proteins were trapped in both of the two S. aureus strains NCTC8325-4 and Newman. About one-third of the trapped proteins are previously shown to be unstable or to be substrates of ClpP in other bacteria, supporting the validity of the ClpP-TRAP. This group of proteins encompassed the transcriptional regulators CtsR and Spx, the ClpC adaptor proteins McsB and MecA, and the cell division protein FtsZ. Newly identified ClpP substrates include the global transcriptional regulators PerR and HrcA, proteins involved in DNA damage repair (RecA, UvrA, UvrB), and proteins essential for protein synthesis (RpoB and Tuf). Our study hence underscores the central role of Clp-proteolysis in a number of pathways that contribute to the success of S. aureus as a human pathogen.

No abstract

We consider the detection and estimation of a zero-mean Gaussian signal in a wireless sensor network with a coherent multiple access channel, when the fusion center (FC) is configured with a large number of antennas and the wireless channels between the sensor nodes and FC experience Rayleigh fading. For the detection problem, we study the Neyman-Pearson (NP) Detector and Energy Detector (ED), and find optimal values for the sensor transmission gains. For the NP detector which requires channel state information (CSI), we show that detection performance remains asymptotically constant with the number of FC antennas if the sensor transmit power decreases proportionally with the increase in the number of antennas. Performance bounds show that the benefit of multiple antennas at the FC disappears as the transmit power grows. The results of the NP detector are also generalized to the linear minimum mean squared error estimator. For the ED which does not require CSI, we derive optimal gains that maximize the deflection coefficient of the detector, and we show that a constant deflection can be asymptotically achieved if the sensor transmit power scales as the inverse square root of the number of FC antennas. Unlike the NP detector, for high sensor power the multi-antenna ED is observed to , IEEE Transactions on Signal Processing 2 empirically have significantly better performance than the single-antenna implementation. A number of simulation results are included to validate the analysis.

No abstract

BackgroundHyperuricemia is a common and serious public health problem. There has been no broad epidemiological survey of hyperuricemia in China, especially in Tibetan area. This study was therefore investigated the prevalence of hyperuricemia and its correlated factors among people aged 18–85 years in Ganzi Tibetan Autonomous Prefecture, Sichuan Province, China.MethodsWe carried out a cross-sectional study among 3093 participants in Ganzi Tibetan Autonomous Prefecture using questionnaires in face-to-face interviews, anthropometric measurements and biochemical tests. We included 1416 subjects with complete data including serum uric acid and medical history to analyze the prevalence of hyperuricemia and correlated factors. Hyperuricemia was defined as a fasting serum uric acid level higher than 420 μmol/L in men and 360 μmol/L in women.ResultsThe overall crude prevalence of hyperuricemia was 37.2%, and was greater in men than women (41% vs 34.4%, P = 0.011). The age-adjusted prevalence was 33.0%. Characteristics linked to hyperuricemia were farmers-herdsmen (OR: 1.749, 95% CI: 1.022–2.992), low to moderate education level (low OR:1.57, 95% CI: 1.102–2.237; moderate OR: 1.86, 95% CI: 1.167–2.963), current drinking (OR: 1.795, 95% CI: 1.193–2.702), hypertension (OR: 1.48, 95% CI: 1.091–2.006), higher body mass index (1 unit increase) (OR: 1.116, 95% CI: 1.077–1.156) and higher serum creatinine (1 unit increase) (OR: 1.046, 95% CI: 1.034–1.059). Serum uric acid was positively related to triglycerides and total cholesterol and negatively related to high density lipoprotein cholesterol in all subjects. Hyperuricemia was a risk factor for high triglyceride ((OR: 2.13, 95% CI: 1.156–3.9266) and high total cholesterol (OR: 2.313, 95% CI: 1.364–3.923) in men and for high low-density lipoprotein cholesterol (OR: 2.696, 95% CI: 1.386–5.245) in women.ConclusionThere is a high prevalence of hyperuricemia in Ganzi Tibetan Autonomous Prefecture. The government needs to prevent and manage hyperuricemia in this area.

Objective: To compare the dietary intake of Chinese people living in Pan Yu, Hong Kong, San Francisco and Sydney with respect to cardiovascular health, using the Mediterranean diet score, examining the effects of age, gender, urbanization and acculturation on the diet score. Subjects: A total of 500 men and 510 women in Hong Kong were recruited as a territory-wide strati®ed random sample. Subjects were recruited in response to local advertisements for the other three sites: Pan Yu, 58 men, 95 women; San Francisco, 166 men, 192 women; Sydney, 95 men, 73 women. Method: Food-frequency questionnaire over a 7 week period. A highahealthy score was taken as 4 for men and 3 for women, representing a dietary pattern bene®cial for cardiovascular health. Results: In Hong Kong, more women in the middle age group (35 ± 54) had a high score than other age groups, and overall more women had high scores than men. In comparing the four geographical regions, Pan Yu had the highest number of subjects with high score, and Hong Kong had the lowest. With the exception of the younger population and men in Hong Kong, the percentage of the population with a high score in all sites is greater than among elderly Greeks consuming a more traditional heart-healthy Mediterranean diet. Conclusion: Considerable variations in Chinese dietary patterns exist with respect to age, gender and geographic location. Overall, the Chinese diet is comparable to the Mediterranean diet and may be expected to have similar health bene®ts that have been documented for the traditional Mediterranean diet.

No abstract