Menstruation is the release of the endometrium with bleeding every month, except during pregnancy. Before or during menstruation, a woman may experience stiffness or abdominal cramps, mood fluctuations and other physical and psychological disorders, which is termed as premenstrual syndrome (PMS). The aim of this research is to observe and value the effect of dark chocolate on clinical symptoms of PMS. This research is an experimental prospective, using experimental design with one group pre and post test. Subjects were 30 women aged 18-22 years. Every day for 2 weeks before menstruation period, subjects took 20 gram of dark chocolate, then were asked to answer questionaire. The data measured is the score as well as individual PMS symptoms before and after eating dark chocolate, was analyzed using a nonparametric Wilcoxon test, followed by McNemar chi square with α=0.05. A highly significant decrease was found in anxiety symptoms, whereas statistically significant reduction was found in fatigue or feeling tired, cramps abdominal, bloating, diarrhea, headache, back pain, change in appetite, muscle or joint pain, and problems in concentration. But the symptom of acne complaint was increased from 73.3% to 76.7%. Consumption of dark chocolate reduces premenstrual syndrome scores on women aged 18-22 years. Keywords: dark chocolate, premenstrual syndrome
Increasing globalization makes humans need the knowledge to compete globally. One way to increase knowledge is by reading. Reading comprehension is the process of interpreting a reading in order to gain a thorough knowledge of the passage. Therefore it is necessary to consume beverages to improve energy and cognitive function. In this study, the researcher used yellow turmeric rhizome steeping as an enhancer of cognitive function. The objective of this research was to determine the effect of consuming yellow turmeric rhizome steeping on the cognitive function which is reading comprehension. This study was quasi-experimental, comparative using pretest and post-test design, conducted on 30 men aged between 18-22 years. Participants were asked to do a reading comprehension test (pretest) than consume 200 cc of water mixed with 10 grams of yellow turmeric rhizome powder. Participants took rest for 90 minutes and asked to do a reading comprehension test (post-test). The measured data was the reading comprehension test score, in the form of a correct answer of 10 questions. Data were analyzed using Wilcoxon Signed Rank Test. The average score of correct answers increased very significantly, before consuming yellow turmeric steeping was 47,33 to 73,33 after consuming yellow turmeric rhizome steeping with p < 0,001. Therefore yellow turmeric rhizome steeping increases reading comprehension.
Dental 13,37mL (p=0,000). Average salivary acidity after chewing xylitol gum increased very significantyly from 6,47 to 7,36(p=0,000). The research concludes that chewing xylitol gum increases salivary volume and acidity.
The number of cancer patient is increasing, while a really effective therapy has not yet been discovered. One concept of carcinogenesis is the relation between chronic inflammation and cancer. Cyclooxygenase-2 (COX-2) has a carcinogenic effect in inflamed and malignant tissues. Red Fruit contains carotenoid that can suppress COX-2 gene expression and tocopherol, which is a potent inhibitor of COX-2. The purpose of this study is to determine cytotoxic activity of Red Fruit oil and its effect on COX-2 gene expression. The experiment used 5 dosages of Red Fruit, 100, 200, 300, 400, and 500 µg/mL, exposed to Raji cells. However, unexposed Raji cells were used as control. Cytotoxic activities were evaluated by MTT Assay, while Lethal Concentration50 (LC50) was determined through regression-correlation analysis. Red Fruit oil effect on COX-2 gene expression was evaluated by Reversed Transcriptase Chain Reaction (RT-PCR) method and electrophoresis. Electrophoresis bands were analyzed by Scion Image for Windows. Optical Integrated Density (OID) of unexposed and exposed groups were statistically analyzed with one way Analysis of Variance (ANOVA), followed by Duncan test with α=0.05. The results showed that Red Fruit had a cytotoxic activity on Raji cells with LC50 of331.42 µg/mL. Red Fruit suppressed COX-2 gene expression with an effective dosage obtained at 500 µg/mL. Keywords: red fruit, cytotoxicity, cox-2 gene expression, raji cells
Ketahanan berolahraga menunjang latihan fisik yang optimal untuk meningkatkan derajat kesehatan dan kebugaran jasmani. Penurunan kapasitas ketahanan olahraga disebabkan oleh dehidrasi dan penurunan karbohidrat dalam otot selama melakukan latihan. Air kelapa berpotensi sebagai minuman olahraga karena memiliki derajat keasaman yang rendah, gula seimbang, kandungan mineral, dan bersifat isotonis. Penelitian ini bertujuan mengetahui efek konsumsi air kelapa terhadap ketahanan dan kebugaran berolahraga diukur dari jarak tempuh dan VO 2 max selama latihan lari. Penelitian dilakukan di Lapangan FPOK UPI Bandung periode Juli 2015-Februari 2016. Bahan penelitian yang digunakan adalah air kelapa dalam kemasan. Air mineral, air gula 5%, dan minuman olahraga isotonik yang digunakan sebagai pembanding. Subjek penelitian adalah 120 orang laki-laki, berusia 18-23 tahun yang dibagi menjadi 4 kelompok untuk tiap-tiap bahan uji. Setelah pemanasan, subjek berlari secepatnya selama 30 menit. Bahan uji diberikan sebelum dan setiap 10 menit selama lari. Jarak yang ditempuh dicatat dalam satuan meter. Analisis dengan one-way ANOVA yang dilanjutkan dengan uji least significant difference (LSD) dengan α<0,05. Jarak tempuh terpanjang rata-rata dan VO 2 max tertinggi didapatkan pada kelompok perlakuan air kelapa, diikuti kelompok air gula 5%, minuman olahraga isotonik, dan air mineral (p<0,01). Simpulan, konsumsi air kelapa sebelum dan selama latihan olahraga lari dapat meningkatkan ketahanan olahraga pada laki-laki dewasa bukan atlet.
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