Multicomponent reactions (MCRs) are composed of three or more reagents in which the final
product has all or most of the carbon atoms from its starting materials. These reactions represent, in the
medicinal chemistry context, great potential in the research for new bioactive compounds, since their products
can present great structural complexity. The aim of this review is to present the main multicomponent reactions
since the original report by Strecker in 1850 from nowadays, covering their evolution, highlighting their
significance in the discovery of new bioactive compounds. The use of MCRs is, indeed, a growing field of
interest in the synthesis of bioactive compounds and approved drugs, with several examples of commerciallyavailable
drugs that are (or can be) obtained through these protocols.
Understanding habitat-level variation in community structure provides an informed basis for natural resources’ management. Reef fishes are a major component of tropical marine biodiversity, but their abundance and distribution are poorly assessed beyond conventional SCUBA diving depths. Based on a baited-video survey of fish assemblages in Southwestern Atlantic’s most biodiverse region we show that species composition responded mainly to the two major hard-bottom megahabitats (reefs and rhodolith beds) and to the amount of light reaching the bottom. Both megahabitats encompassed typical reef fish assemblages but, unexpectedly, richness in rhodolith beds and reefs was equivalent. The dissimilar fish biomass and trophic structure in reefs and rhodolith beds indicates that these systems function based on contrasting energy pathways, such as the much lower herbivory recorded in the latter. Rhodolith beds, the dominant benthic megahabitat in the tropical Southwestern Atlantic shelf, play an underrated role as fish habitats, and it is critical that they are considered in conservation planning.
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